Folate and alcohol consumption and the risk of lung cancer
Abstract
Because both folate deficiency and alcohol intake have been hypothesized to be lung cancer risk factors, the authors examined the effect of folate and alcohol consumption on risk of lung cancer in a case-control study conducted 1980-1984. Usual dietary intake of 450 histologically confirmed lung cancer cases and 902 controls, all Western New York residents, was ascertained using a modified food frequency questionnaire. Folate intake was not associated with lung cancer risk. After adjusting for age, cigarette smoking, education, and carotene intake, the odds ratio (OR) for the highest category of folate intake was 1.59 in males and 1.34 in females. There was some indication of a protective effect of folate only among women who never smoked. There was a suggestion of a positive association of alcohol intake with lung cancer risk in males, independent of age, education, cigarette smoking, and carotene. Consumers of more than 9 beers per month had an OR of 1.51 compared to non-drinkers. In both sexes, there was an indication of an interaction between beer ingestion and cigarette smoking. While folate intake did not appear to affect risk of lung cancer, the association of alcohol intake with risk independent of cigarette smoking deserves further inquiry.
- Authors:
-
- State Univ. of New York, Buffalo (United States)
- Publication Date:
- OSTI Identifier:
- 5372324
- Report Number(s):
- CONF-9104107-
Journal ID: ISSN 0892-6638; CODEN: FAJOE
- Resource Type:
- Conference
- Journal Name:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States)
- Additional Journal Information:
- Journal Volume: 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; Journal ID: ISSN 0892-6638
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ETHANOL; CARCINOGENESIS; FOLIC ACID; NUTRITIONAL DEFICIENCY; LUNGS; NEOPLASMS; RISK ASSESSMENT; SEX DEPENDENCE; ALCOHOLS; AMINO ACIDS; AROMATICS; AZAARENES; BODY; CARBOXYLIC ACIDS; DISEASES; DRUGS; HEMATINICS; HEMATOLOGIC AGENTS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PATHOGENESIS; PTERIDINES; RESPIRATORY SYSTEM; VITAMIN B GROUP; VITAMINS; 560300* - Chemicals Metabolism & Toxicology
Citation Formats
Bandera, E V, Graham, S, Freudenheim, J L, Marshall, J R, Haughey, B P, Swanson, M, Brasure, J, and Wilkinson, G. Folate and alcohol consumption and the risk of lung cancer. United States: N. p., 1991.
Web.
Bandera, E V, Graham, S, Freudenheim, J L, Marshall, J R, Haughey, B P, Swanson, M, Brasure, J, & Wilkinson, G. Folate and alcohol consumption and the risk of lung cancer. United States.
Bandera, E V, Graham, S, Freudenheim, J L, Marshall, J R, Haughey, B P, Swanson, M, Brasure, J, and Wilkinson, G. 1991.
"Folate and alcohol consumption and the risk of lung cancer". United States.
@article{osti_5372324,
title = {Folate and alcohol consumption and the risk of lung cancer},
author = {Bandera, E V and Graham, S and Freudenheim, J L and Marshall, J R and Haughey, B P and Swanson, M and Brasure, J and Wilkinson, G},
abstractNote = {Because both folate deficiency and alcohol intake have been hypothesized to be lung cancer risk factors, the authors examined the effect of folate and alcohol consumption on risk of lung cancer in a case-control study conducted 1980-1984. Usual dietary intake of 450 histologically confirmed lung cancer cases and 902 controls, all Western New York residents, was ascertained using a modified food frequency questionnaire. Folate intake was not associated with lung cancer risk. After adjusting for age, cigarette smoking, education, and carotene intake, the odds ratio (OR) for the highest category of folate intake was 1.59 in males and 1.34 in females. There was some indication of a protective effect of folate only among women who never smoked. There was a suggestion of a positive association of alcohol intake with lung cancer risk in males, independent of age, education, cigarette smoking, and carotene. Consumers of more than 9 beers per month had an OR of 1.51 compared to non-drinkers. In both sexes, there was an indication of an interaction between beer ingestion and cigarette smoking. While folate intake did not appear to affect risk of lung cancer, the association of alcohol intake with risk independent of cigarette smoking deserves further inquiry.},
doi = {},
url = {https://www.osti.gov/biblio/5372324},
journal = {FASEB Journal (Federation of American Societies for Experimental Biology); (United States)},
issn = {0892-6638},
number = ,
volume = 5:4,
place = {United States},
year = {Mon Mar 11 00:00:00 EST 1991},
month = {Mon Mar 11 00:00:00 EST 1991}
}