Radiographic visualization of intraosseous Thorotrast in vivo

Journal Article · Fri Feb 01 00:00:00 EST 1980 · Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.134.2.378· OSTI ID:5367727

Arndt, J H ^[1]; Hosford, G; Kingsley, W B; Tillery, G W; Gaulden, M E

---

1. Baylor Univ., Dallas, TX

The carcinogenic effects of residual Thorotrast in human tissues makes recognition of its various radiographic patterns important. Most radiologists are familiar with the appearance of the liver, spleen, and upper abdominal lymph nodes after intravascular injection of the colloidal suspension. Radiographic visualization of intraosseous Thorotrast deposits in the living patient has not, to our knowledge, been reported. An estimated 1% to 10% of intravascularly administered Thorotrast is ultimately sequestered by the reticuloendothelial system of cancellous bone. Since the radiographic density of normal bone is high, and the quantity of thorium per unit volume of bone low, it would not seem possible to detect Thorotrast deposits in normal bone. However, the colloidal materials is picked up by bone histiocytes that tend to aggregate into clusters. Against a background of demineralized bone, these aggregates (or summation thereof) become visible.

• OSTI ID: 5367727
• Journal Information: Am. J. Roentgenol.; (United States), Vol. 134:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
BONE CELLS
RADIONUCLIDE KINETICS
THOROTRAST
BIOLOGICAL LOCALIZATION
BIOMEDICAL RADIOGRAPHY
INTRAVENOUS INJECTION
PATIENTS
SKELETON
ACTINIDE COMPOUNDS
ANIMAL CELLS
BODY
CHALCOGENIDES
COLLOIDS
CONNECTIVE TISSUE CELLS
CONTRAST MEDIA
DIAGNOSTIC TECHNIQUES
DISPERSIONS
INJECTION
INTAKE
MEDICINE
NUCLEAR MEDICINE
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOCOLLOIDS
RADIOLOGY
SOMATIC CELLS
THORIUM COMPOUNDS
THORIUM OXIDES
560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)
550602 - Medicine- External Radiation in Diagnostics- (1980-)