Thyroid abnormalities associated with treatment of malignant lymphoma

Journal Article · Mon Jun 01 00:00:00 EDT 1981 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19810601)47:11<2704::AID-CNCR2820471129>3.0.CO;2-G· OSTI ID:5365687

Tamura, K; Shimaoka, K; Friedman, M

The effects on the thyroid of radiation therapy to the neck and/or chemotherapy were investigated in 54 Hodgkin's and 72 non-Hodgkin's lymphoma patients. These patients had received radiation therapy with doses ranging from 2000 to 4000 rad (median 3600 rad) to the cervical or mantle fields and/or multiple-agent chemotherapy following usual staging procedures. Palpable abnormalities of the thyroid were found in 15 patients. The patients with irradiation to the neck had a higher incidence of hypothyroidism than those patients treated with chemotherapy alone (31/74 vs. 8/52, P less than 0.001 for TSH and 10/74 vs. 1/52, P less than 0.025 for T4). A higher frequency of elevated serum TSH levels and antithyroid antibodies were also observed in patients receiving radiation therapy alone to the neck than in those receiving both radiation therapy and chemotherapy (19/33 vs. 12/41, P less than 0.025 for TSH and 16/33 vs. 7/41, p less than 0.01 for antibodies), suggesting that chemotherapy agents may reduce the thyroid dysfunction induced by irradiation. There was no difference in prevalence of elevated TSH levels following irradiation to the neck between patients in whom lymphangiogram was or was not performed (21/51 vs. 10/23).

• OSTI ID: 5365687
• Journal Information: Cancer (Philadelphia); (United States), Vol. 47:11
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LYMPHOMAS
RADIOTHERAPY
SIDE EFFECTS
THYROID
BIOLOGICAL RADIATION EFFECTS
CHEMOTHERAPY
HEAD
HYPOTHYROIDISM
LOCAL IRRADIATION
NECK
PATIENTS
RADIATION DOSES
RADIOINDUCTION
TSH
BIOLOGICAL EFFECTS
BODY
BODY AREAS
DISEASES
DOSES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
IRRADIATION
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RADIOLOGY
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man