Meningosis prophylaxis with intrathecal /sup 198/Au-colloid and methotrexate in childhood acute lymphocytic leukemia
Since 1972, telecobalt irradiation plus intrathecal methotrexate (ITMTX) has been successfully replaced in Jena by intrathecal colloidal radioactive gold (/sup 198/Au) plus ITMTX for meningosis prophylaxis in leukemia. Seventy-three children with acute lymphocytic leukemia (ALL) were given 1.24-4.89 mCi (45.8-181 MBq) of colloidal 198Au IT after successful initiation of remission. During cytostatic therapy, the following relapses occurred: meningosis leucaemica, five patients (6.8%); bone-marrow relapse and the meningosis leucaemica, one patient; and bone-marrow relapse, 20 patients (27.4%). In 18 children, combination chemotherapy was terminated after two and a half or three years of treatment. After that time, one meningeal relapse and six bone-marrow relapses occurred. Within the first 24 hours after application of radioactive gold, headaches, vomiting, and fever occurred in less than 10% of the children. An apathy syndrome, leukecephalopathy, or severe infections, were not observed in a single case. Radioactive gold spreads in the subarachnoid space and is phagocytized by the arachnoidea. The tumoricide effect extends selectively over the space of distribution of the latent meningosis leucaemia. The cerebral parenchyma remains unaffected by radiation. Thus, radioactive gold may be preferable to telecobalt irradiation in preventing central nervous system leukemia.
- Research Organization:
- Friedrich-Schiller-University, Jena
- OSTI ID:
- 5365326
- Journal Information:
- Cancer (Philadelphia); (United States), Vol. 49:2
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CENTRAL NERVOUS SYSTEM
BIOLOGICAL RADIATION EFFECTS
GOLD 198
ISOTOPE APPLICATIONS
LEUKEMIA
RADIOTHERAPY
CHILDREN
FEVER
INTERNAL IRRADIATION
MENINGES
METHOTREXATE
PAIN
PATIENTS
RADIOCOLLOIDS
SIDE EFFECTS
TRACHEA
VOMITING
AGE GROUPS
ANTIMETABOLITES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
COLLOIDS
DAYS LIVING RADIOISOTOPES
DISEASES
DISPERSIONS
DRUGS
GOLD ISOTOPES
HEAVY NUCLEI
HEMIC DISEASES
IRRADIATION
ISOTOPES
MEDICINE
MEMBRANES
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
RESPIRATORY SYSTEM
SYMPTOMS
THERAPY
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man