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Title: Effect of pressure and intimal damage on /sup 131/I-albumin and (/sup 14/C)sucrose spaces in aorta

Abstract

To measure the distribution volume for sucrose and albumin in the media of the rabbit thoracic aorta, we studied the uptake of tracers in vitro. In most cases the tracers were applied to both luminal and adventitial surfaces at the same concentration. When transmural convection was prevented by pressurization of the arteries with air, there was a decrease in sucrose space (19% at 70 mmHg and 28% at 180 mmHg) and in albumin space (60% at 70 mmHg and 66% at 180 mmHg), compared with the respective spaces in relaxed arteries (0.42 for sucrose and 0.08 for albumin). Much smaller changes were found when intact vessels were pressurized with liquid (insignificant for sucrose, decreases of 24% at 70 mmHg and 14% at 180 mmHg for albumin). Removal of the endothelium, which increases transmural fluid flux, increased the space for sucrose (not significantly at 70 mmHg and 17% at 180 mmHg) and particularly for albumin (100% at 70 mmHg and 250% at 180 mmHg). We conclude that the interstitial volume and consequently the protein space within the media can be modified both by distending stresses applied to the vessel and by transmural fluid flux.

Authors:
;
Publication Date:
Research Org.:
Imperial College, London, England
OSTI Identifier:
5359435
Resource Type:
Journal Article
Journal Name:
Am. J. Physiol.; (United States)
Additional Journal Information:
Journal Volume: 253
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ALBUMINS; TISSUE DISTRIBUTION; AORTA; BIOLOGICAL STRESS; SACCHAROSE; ALGORITHMS; CARBON 14 COMPOUNDS; ENDOTHELIUM; IODINE 131; RABBITS; TRACER TECHNIQUES; ANIMAL TISSUES; ANIMALS; ARTERIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; CARBOHYDRATES; CARDIOVASCULAR SYSTEM; DAYS LIVING RADIOISOTOPES; DISACCHARIDES; DISTRIBUTION; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATHEMATICAL LOGIC; NUCLEI; ODD-EVEN NUCLEI; OLIGOSACCHARIDES; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; SACCHARIDES; TISSUES; VERTEBRATES; 551001* - Physiological Systems- Tracer Techniques

Citation Formats

Tedgui, A, and Lever, M J. Effect of pressure and intimal damage on /sup 131/I-albumin and (/sup 14/C)sucrose spaces in aorta. United States: N. p., 1987. Web.
Tedgui, A, & Lever, M J. Effect of pressure and intimal damage on /sup 131/I-albumin and (/sup 14/C)sucrose spaces in aorta. United States.
Tedgui, A, and Lever, M J. 1987. "Effect of pressure and intimal damage on /sup 131/I-albumin and (/sup 14/C)sucrose spaces in aorta". United States.
@article{osti_5359435,
title = {Effect of pressure and intimal damage on /sup 131/I-albumin and (/sup 14/C)sucrose spaces in aorta},
author = {Tedgui, A and Lever, M J},
abstractNote = {To measure the distribution volume for sucrose and albumin in the media of the rabbit thoracic aorta, we studied the uptake of tracers in vitro. In most cases the tracers were applied to both luminal and adventitial surfaces at the same concentration. When transmural convection was prevented by pressurization of the arteries with air, there was a decrease in sucrose space (19% at 70 mmHg and 28% at 180 mmHg) and in albumin space (60% at 70 mmHg and 66% at 180 mmHg), compared with the respective spaces in relaxed arteries (0.42 for sucrose and 0.08 for albumin). Much smaller changes were found when intact vessels were pressurized with liquid (insignificant for sucrose, decreases of 24% at 70 mmHg and 14% at 180 mmHg for albumin). Removal of the endothelium, which increases transmural fluid flux, increased the space for sucrose (not significantly at 70 mmHg and 17% at 180 mmHg) and particularly for albumin (100% at 70 mmHg and 250% at 180 mmHg). We conclude that the interstitial volume and consequently the protein space within the media can be modified both by distending stresses applied to the vessel and by transmural fluid flux.},
doi = {},
url = {https://www.osti.gov/biblio/5359435}, journal = {Am. J. Physiol.; (United States)},
number = ,
volume = 253,
place = {United States},
year = {Tue Dec 01 00:00:00 EST 1987},
month = {Tue Dec 01 00:00:00 EST 1987}
}