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Title: Deleterious background selection with recombination

An analytic expression for the expected nucleotide diversity is obtained for a neutral locus in a region with deleterious mutation and recombination. Our analytic results are used to predict levels of variation for the entire third chromosome of Drosophila melanogaster. The predictions are consistent with the low levels of variation that have been observed at loci near the centromeres of the third chromosome of D. melanogaster. However, the low levels of variation observed near the tips of this chromosome are not predicted using currently available estimates of the deleterious mutation rate and of selection coefficients. If considerably smaller selection coefficients are assumed, the low observed levels of variation at the tips of the third chromosome are consistent with the background selection model. 33 refs., 4 figs., 1 tab.
Authors:
 [1] ;  [2]
  1. Univ. of California, Irvine, CA (United States)
  2. National Institute of Environmental Health Sciences, Research Triangle Park, NC (United States)
Publication Date:
OSTI Identifier:
535353
Resource Type:
Journal Article
Resource Relation:
Journal Name: Genetics; Journal Volume: 141; Journal Issue: 4; Other Information: PBD: Dec 1995
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 99 MATHEMATICS, COMPUTERS, INFORMATION SCIENCE, MANAGEMENT, LAW, MISCELLANEOUS; DROSOPHILA; GENETICS; GENES; GENE RECOMBINATION; GENETIC VARIABILITY; GENE MUTATIONS; GENETIC MAPPING; MUTATION FREQUENCY; NUCLEOTIDES; ANALYTIC FUNCTIONS; CHROMOSOMES; CHROMOSOMAL ABERRATIONS; CENTROMERES