Biological effects summary report: 4,4'-methylenedianiline
The Center for Assessment of Chemical and Physical Hazards was requested by the Department of Energy (DOE) to develop a Biological Effects Summary Report for 4,4'-methylenedianiline (MDA). The literature regarding MDA toxicity was reviewed and a risk assessment analysis was performed based on animal tumor data, structurally similar compounds, and human effects data. In man, acute exposures to MDA have caused epigastric pain, fever, jaundice, and oher symptoms consistent with hepatitis. These effects appear to be reversible. No liver damage has yet been observed from chronic exposure. Chronic skin effects disappear when MDA exposure stops. Skin sensitivity also occurs in some individuals. Recent findings suggest a link between exposure to MDA and the occurrence of bladder cancer in man. Studies indicate that the skin is a major route of exposure in the development of these health effects. In animals, chronic administration of MDA produces hepatic cirrhosis, liver lesions, and enlargement of the spleen, liver, and kidneys. MDA has also proved to be carcinogenic in rats and mice, causing liver, thyroid and several other tumors. Compounds structurally similar to MDA are also known to be carcinogenic in man and animals. Based on these findings, an interim exposure limit of 0.08 mg/m/sup 3/ (0.01 ppM) was recommended for an average concentration exposure to employees during an 8-h work shift. 52 refs., 5 figs., 16 tabs.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 5352834
- Report Number(s):
- BNL-51903; ON: DE85017376
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products. Original copy available until stock is exhausted
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AMINES
BIOLOGICAL EFFECTS
HEALTH HAZARDS
MAXIMUM PERMISSIBLE EXPOSURE
ACUTE EXPOSURE
AROMATICS
CARCINOGENESIS
CHRONIC EXPOSURE
JAUNDICE
KIDNEYS
LIVER CIRRHOSIS
MEN
MICE
RATS
SKIN ABSORPTION
SPLEEN
ABSORPTION
ANIMALS
BODY
DIGESTIVE SYSTEM DISEASES
DISEASES
HAZARDS
MALES
MAMMALS
MAN
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PATHOLOGICAL CHANGES
PRIMATES
RODENTS
SAFETY STANDARDS
STANDARDS
SYMPTOMS
UPTAKE
VERTEBRATES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)