Does radiation-induced abrogation of skin Langerhans cell functions lead to enhanced incidence of skin tumors in patients with genetic disorders of DNA repair
Journal Article
·
· Cancer Invest.; (United States)
A hypothesis is presented which states that persons with the genetic disorders xeroderma pigmentosum and ataxia-telangiectasia, manifested by a deficiency of DNA repair, develop cutaneous tumors due to the elimination of reticuloendothelial system cells (Langerhans cells) in the skin, and the subsequent loss of control of epidermal cellular elements. 84 references.
- Research Organization:
- The Hebrew Univ. of Jerusalem (Israel)
- OSTI ID:
- 5350164
- Journal Information:
- Cancer Invest.; (United States), Vol. 5:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NEOPLASMS
RADIOINDUCTION
SKIN
DNA REPAIR
PANCREAS
PATIENTS
REVIEWS
TELANGIECTASIS
XERODERMA PIGMENTOSUM
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
DIGESTIVE SYSTEM
DISEASES
DOCUMENT TYPES
ENDOCRINE GLANDS
GLANDS
ORGANS
RECOVERY
REPAIR
SKIN DISEASES
VASCULAR DISEASES
560151* - Radiation Effects on Animals- Man
NEOPLASMS
RADIOINDUCTION
SKIN
DNA REPAIR
PANCREAS
PATIENTS
REVIEWS
TELANGIECTASIS
XERODERMA PIGMENTOSUM
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
DIGESTIVE SYSTEM
DISEASES
DOCUMENT TYPES
ENDOCRINE GLANDS
GLANDS
ORGANS
RECOVERY
REPAIR
SKIN DISEASES
VASCULAR DISEASES
560151* - Radiation Effects on Animals- Man