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Title: Effect of MPG on radiation-induced odontogenic tissue metaplasia

Abstract

This investigation monitored the effect of 2-mercaptopropionylglycine (MPG) in reducing radiation damage to the tooth-forming tissues. Fifty rats were exposed to x-ray doses of between 3 and 19 Gy directed toward the maxillary incisor germinal centers. Half of the animals were given an injection of MPG before irradiation, while the other rats were injected with saline solution. Administration of MPG did not significantly reduce the frequency of dentinal niche formation relative to the control teeth. The average lengths and percentage depths of the apicoincisal niches were statistically smaller in the groups treated with MPG. Although statistically significant, the mild protective effect of MPG was not clinically important because damage to the irradiated teeth was still extensive.

Authors:
; ;
Publication Date:
Research Org.:
Univ. of Detroit School of Dentistry, MI (USA)
OSTI Identifier:
5350030
Resource Type:
Journal Article
Journal Name:
Oral Surg., Oral Med., Oral Pathol.; (United States)
Additional Journal Information:
Journal Volume: 65:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; RADIOPROTECTIVE SUBSTANCES; RADIOSENSITIVITY EFFECTS; TEETH; BIOLOGICAL RADIATION EFFECTS; DENTIN; DENTISTRY; RADIATION DOSES; RATS; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; DIGESTIVE SYSTEM; DOSES; DRUGS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MAMMALS; MEDICINE; ORAL CAVITY; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Geist, J R, Kafrawy, A H, and Shupe, R E. Effect of MPG on radiation-induced odontogenic tissue metaplasia. United States: N. p., 1988. Web. doi:10.1016/0030-4220(88)90202-2.
Geist, J R, Kafrawy, A H, & Shupe, R E. Effect of MPG on radiation-induced odontogenic tissue metaplasia. United States. https://doi.org/10.1016/0030-4220(88)90202-2
Geist, J R, Kafrawy, A H, and Shupe, R E. 1988. "Effect of MPG on radiation-induced odontogenic tissue metaplasia". United States. https://doi.org/10.1016/0030-4220(88)90202-2.
@article{osti_5350030,
title = {Effect of MPG on radiation-induced odontogenic tissue metaplasia},
author = {Geist, J R and Kafrawy, A H and Shupe, R E},
abstractNote = {This investigation monitored the effect of 2-mercaptopropionylglycine (MPG) in reducing radiation damage to the tooth-forming tissues. Fifty rats were exposed to x-ray doses of between 3 and 19 Gy directed toward the maxillary incisor germinal centers. Half of the animals were given an injection of MPG before irradiation, while the other rats were injected with saline solution. Administration of MPG did not significantly reduce the frequency of dentinal niche formation relative to the control teeth. The average lengths and percentage depths of the apicoincisal niches were statistically smaller in the groups treated with MPG. Although statistically significant, the mild protective effect of MPG was not clinically important because damage to the irradiated teeth was still extensive.},
doi = {10.1016/0030-4220(88)90202-2},
url = {https://www.osti.gov/biblio/5350030}, journal = {Oral Surg., Oral Med., Oral Pathol.; (United States)},
number = ,
volume = 65:1,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1988},
month = {Fri Jan 01 00:00:00 EST 1988}
}