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Title: Neurotoxic metabolites of ''commercial hexane'' in the urine of shoe factory workers

Urinary metabolites were tested in 41 shoe-factory workers exposed to a mixture of 10 solvents among which ''commercial hexane'' was the prevailing component. Cyclohexanol, 2-methyl-2-pentanol, 3-methyl-2-pentanol, and trichloroethanol were determined in connection with exposure to cyclohexane, 2-methylpentane, 3-methylpentane, and trichloroethylene, respectively. 2-Hexanol, 2,5-hexanedione, 2,5-dimethylfuran, and gamma-valerolactone were all determined in connection with n-hexane exposure only. 2,5-Hexanedione was the principal n-hexane metabolite found in the workers' urine. This finding of the experimentally proven neurotoxin 2,5-hexanedione in the urine of shoe-factory workers exposed to ''commercial hexane'' is consistent with the idea that this compound is responsible for the development of neuropathy in this group of individuals.
Authors:
; ;
Publication Date:
OSTI Identifier:
5335840
Resource Type:
Journal Article
Resource Relation:
Journal Name: Clin. Toxicol.; (United States); Journal Volume: 18:12
Research Org:
Institute of Occupational Medicine, University of Padua-Verona, Italy
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; NERVOUS SYSTEM DISEASES; EPIDEMIOLOGY; ORGANIC SOLVENTS; TOXICITY; ALKANES; HEALTH HAZARDS; HEXANE; MANUFACTURERS; OCCUPATIONAL SAFETY; PERSONNEL; TEXTILES; URINE; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY FLUIDS; DISEASES; HAZARDS; HYDROCARBONS; MATERIALS; ORGANIC COMPOUNDS; SAFETY; SOLVENTS; WASTES 560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)