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Title: Cysteamine effects on somatostatin, catecholamines, pineal NAT and melatonin in rats

Abstract

The thiol reagent cysteamine was administered to adult male rats with the aim of investigating its effect on different neural and pineal components. As expected, immunoreactive somatostatin decreased in the median eminence (ME) (p less than 0.05) and gastric antrum (p less than 0.05) after cysteamine; however, no significant change was observed in the pineal IRS content after drug treatment. A decrease in norepinephrine was observed in the ME (p less than 0.001), hypothalamus (p less than 0.001) and pineal gland (p less than 0.05), together with a rise in ME (p less than 0.005) and hypothalamic dopamine (p less than 0.005) content; these results are consistent with a dopamine-beta-hydroxylase inhibiting effect of cysteamine. No effect was observed on hypothalamic serotonin and 5-hydroxyindole-acetic acid content. Pineal N-acetyltransferase (NAT) activity was significantly higher (p less than 0.05) after cysteamine than after saline, but no statistically significant effect was observed on pineal melatonin content. The mechanism involved in the NAT rise is presumably not related to the known stimulatory effect of norepinephrine, which fell after cysteamine. It is suggested that cysteamine may act at an intracellular level, inhibiting NAT degradation, an effect demonstrated in vitro and thought to be related to amore » thiol:disulfide exchange mechanism.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Autonomous Univ., Barcelona, Spain
OSTI Identifier:
5324571
Resource Type:
Journal Article
Journal Name:
Brain Res. Bull.; (United States)
Additional Journal Information:
Journal Volume: 3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MEA; BIOLOGICAL EFFECTS; CATECHOLAMINES; DOPAMINE; HYPOTHALAMUS; MELATONIN; NORADRENALINE; RATS; SEROTONIN; SOMATOSTATIN; ADRENAL HORMONES; AMINES; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZOLES; BODY; BRAIN; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; DRUGS; HETEROCYCLIC COMPOUNDS; HORMONES; HYDROXY COMPOUNDS; INDOLES; MAMMALS; NERVOUS SYSTEM; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; PYRROLES; RADIOPROTECTIVE SUBSTANCES; RODENTS; STEROID HORMONES; SYMPATHOMIMETICS; THIOLS; TRYPTAMINES; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Webb, S M, Champney, T H, Steger, R W, Vaughan, M K, and Reiter, R J. Cysteamine effects on somatostatin, catecholamines, pineal NAT and melatonin in rats. United States: N. p., 1986. Web. doi:10.1016/0361-9230(86)90051-1.
Webb, S M, Champney, T H, Steger, R W, Vaughan, M K, & Reiter, R J. Cysteamine effects on somatostatin, catecholamines, pineal NAT and melatonin in rats. United States. https://doi.org/10.1016/0361-9230(86)90051-1
Webb, S M, Champney, T H, Steger, R W, Vaughan, M K, and Reiter, R J. 1986. "Cysteamine effects on somatostatin, catecholamines, pineal NAT and melatonin in rats". United States. https://doi.org/10.1016/0361-9230(86)90051-1.
@article{osti_5324571,
title = {Cysteamine effects on somatostatin, catecholamines, pineal NAT and melatonin in rats},
author = {Webb, S M and Champney, T H and Steger, R W and Vaughan, M K and Reiter, R J},
abstractNote = {The thiol reagent cysteamine was administered to adult male rats with the aim of investigating its effect on different neural and pineal components. As expected, immunoreactive somatostatin decreased in the median eminence (ME) (p less than 0.05) and gastric antrum (p less than 0.05) after cysteamine; however, no significant change was observed in the pineal IRS content after drug treatment. A decrease in norepinephrine was observed in the ME (p less than 0.001), hypothalamus (p less than 0.001) and pineal gland (p less than 0.05), together with a rise in ME (p less than 0.005) and hypothalamic dopamine (p less than 0.005) content; these results are consistent with a dopamine-beta-hydroxylase inhibiting effect of cysteamine. No effect was observed on hypothalamic serotonin and 5-hydroxyindole-acetic acid content. Pineal N-acetyltransferase (NAT) activity was significantly higher (p less than 0.05) after cysteamine than after saline, but no statistically significant effect was observed on pineal melatonin content. The mechanism involved in the NAT rise is presumably not related to the known stimulatory effect of norepinephrine, which fell after cysteamine. It is suggested that cysteamine may act at an intracellular level, inhibiting NAT degradation, an effect demonstrated in vitro and thought to be related to a thiol:disulfide exchange mechanism.},
doi = {10.1016/0361-9230(86)90051-1},
url = {https://www.osti.gov/biblio/5324571}, journal = {Brain Res. Bull.; (United States)},
number = ,
volume = 3,
place = {United States},
year = {Sat Mar 01 00:00:00 EST 1986},
month = {Sat Mar 01 00:00:00 EST 1986}
}