Mechanisms of contact photosensitivity in mice. IV. Antigen-specific suppressor T cells induced by preirradiation of photosensitizing site to UVB

Journal Article · Thu Mar 01 00:00:00 EST 1984 · J. Immunol.; (United States)

OSTI ID:5323097

Takigawa, M; Miyachi, Y; Toda, K; Yoshioka, A

Mice were successfully contact photosensitized with 3,3',4',5-tetrachlorosalicyanilide (TCSA) plus black light irradiation. Pre-exposure of the photosensitizing site (ca 5 cm/sup 2/) to UVB (280 to 320 nm; 400 mJ/cm/sup 2/) rendered mice unresponsive to a challenge reaction. Cell transfer experiments demonstrated that the spleen from the nonreactive mice contained suppressor T cells (T/sub s/) that were antigen-specific and that blocked the afferent limb of contact photosensitivity to TCSA. To exert suppressive functions, T/sub s/ required another population of cyclophosphamide-sensitive T cells that resided in the spleens of nonsensitized mice. The results provide evidence that UVB-induced aberrant homeostasis of the skin caused a marked suppression of immune system that is associated with the generation of T/sub s/.

• Research Organization: Kyoto Univ., Japan
• OSTI ID: 5323097
• Journal Information: J. Immunol.; (United States), Vol. 132:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
IMMUNOSUPPRESSION
RADIOINDUCTION
LYMPHOCYTES
CELL PROLIFERATION
SKIN
RADIOSENSITIVITY
CHLORINATED AROMATIC HYDROCARBONS
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HALOGENATED AROMATIC HYDROCARBONS
LEUKOCYTES
MAMMALS
MATERIALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
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ORGANS
RADIATIONS
RODENTS
SOMATIC CELLS
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560151* - Radiation Effects on Animals- Man