Evidence of chromosomal instability in neurofibromatosis

Journal Article · Wed May 15 00:00:00 EDT 1985 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19850515)55:10<2434::AID-CNCR2820551022>3.0.CO;2-A· OSTI ID:5322064

Hafez, M; Sharaf, L; Abd el-Nabi, S M; el-Wehedy, G

Blood lymphocytes from six unrelated patients with neurofibromatosis and three normal controls were examined for their response to different doses (0, 75, 150, 300, 400 rad) of x-radiation, as measured by chromosome aberrations (gaps, breaks, dicentrics, centric rings, acentric ring, fragments, and minutes). Cytogenetic studies on phytohemagglutinin-stimulated cells revealed chromosomal instability in the neurofibromatosis lymphocytes as shown by the significant increase in the in the incidence of gaps, breaks and dicentrics. This increase paralleled the increase in the dose of irradiation. The significance of these findings is discussed.

• Research Organization: Mansoura Univ., Egypt
• OSTI ID: 5322064
• Journal Information: Cancer (Philadelphia); (United States), Vol. 10
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LYMPHOCYTES
CHROMOSOMAL ABERRATIONS
GENETIC RADIATION EFFECTS
BLOOD
CHROMOSOMES
DOSE-RESPONSE RELATIONSHIPS
NERVOUS SYSTEM DISEASES
PATIENTS
RADIATION DOSES
X RADIATION
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
GENETIC EFFECTS
IONIZING RADIATIONS
LEUKOCYTES
MATERIALS
MUTATIONS
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
560121* - Radiation Effects on Cells- External Source- (-1987)