skip to main content

Title: Fetal PCB syndrome: clinical features, intrauterine growth retardation and possible alteration in calcium metabolism

Pregnant mothers with Yusho in Fukuoka, Nagasaki and Kochi Prefectures delivered babies with a peculiar clinical manifestation which will be called fetal PCB syndrome (FPS). The birth rate incidences were 3.6% (Fukuoka Prefecture), 4% (Nagasaki Prefecture), 2.9% (Kochi Prefecture) and 3.9% (total). The manifestations consisted of dark brown pigmentation of the skin and the mucous membrane, gingival hyperplasia, exophthalmic edematous eye, dentition at birth, abnormal calcification of the skull as demonstrated by X-ray, rocker bottom heel and high incidence of light for date (low birth weight) babies. The authors suggest that there may be a possible alteration in calcium metabolism in these babies, related to the fragile egg shells observed in PCB-contaminated birds and to the female hormone-enhancing effect of PCB. The high incidence of low birth weight among these newborns and two other similar studies indicated that PCBs suppress fetal growth.
Authors:
;
Publication Date:
OSTI Identifier:
5321327
Resource Type:
Journal Article
Resource Relation:
Journal Name: Environ. Health Perspect.; (United States); Journal Volume: 59
Research Org:
Kurume Univ., Japan
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CALCIUM COMPOUNDS; METABOLISM; CHLORINATED AROMATIC HYDROCARBONS; BIOLOGICAL EFFECTS; PRENATAL EXPOSURE; DISEASE INCIDENCE; EPIDEMIOLOGY; GROWTH; INFANTS; JAPAN; PIGMENTS; PREGNANCY; SKIN; SYMPTOMS; WOMEN; AGE GROUPS; ALKALINE EARTH METAL COMPOUNDS; ANIMALS; AROMATICS; ASIA; BODY; CHILDREN; FEMALES; HALOGENATED AROMATIC HYDROCARBONS; MAMMALS; MAN; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANS; PRIMATES; VERTEBRATES 560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)