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Title: Leucine metabolism in patients with Hepatic Encephalopathy

A primed continuous infusion of (/sup 15/N, 1-/sup 13/C)leucine was used to determine whether increased oxidation and/or protein synthesis of leucine occurs in patients with cirrhosis. Five controls and patients were equilibrated on a metabolic balance diet (0.6 g protein per kg ideal body weight (IBW)). An additional four patients were equilibrated in the same manner with the same type of diet with a protein level of 0.75 g per kg IBW. Plasma leucine and breath CO/sub 2/ enrichments were measured by mass spectrometry. Protein synthesis and leucine metabolism were identical in controls and patients when both were fed a diet with 0.6 g protein/kg IBW. Results indicate that systemic derangements of leucine metabolism are not the cause of Hepatic Encephalopathy.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
5318671
Report Number(s):
CONF-8604222-
Journal ID: CODEN: FEPRA; TRN: 86-028530
Resource Type:
Conference
Resource Relation:
Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States); Journal Volume: 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
Research Org:
Florida State Univ., Tallahassee
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; LEUCINE; METABOLISM; LIVER CIRRHOSIS; PATHOGENESIS; PROTEINS; BIOSYNTHESIS; CARBON 13; CARBON DIOXIDE; MASS SPECTROSCOPY; NITROGEN 15; PATIENTS; TRACER TECHNIQUES; AMINO ACIDS; CARBON COMPOUNDS; CARBON ISOTOPES; CARBON OXIDES; CARBOXYLIC ACIDS; CHALCOGENIDES; DIGESTIVE SYSTEM DISEASES; DISEASES; EVEN-ODD NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; NITROGEN ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; OXIDES; OXYGEN COMPOUNDS; SPECTROSCOPY; STABLE ISOTOPES; SYNTHESIS 550901* -- Pathology-- Tracer Techniques