Generalized peripheral neuropathy in a dental technician exposed to methyl methacrylate monomer

Journal Article · Mon Jul 01 00:00:00 EDT 1991 · Neurology; (United States)

DOI:https://doi.org/10.1212/WNL.41.7.1112· OSTI ID:5317773

Donaghy, M; Rushworth, G; Jacobs, J M ^[1]

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1. Department of Clinical Neurology, Radcliffe Infirmary, Oxford (England)

A 58-year-old dental prosthetic technician developed generalized sensorimotor peripheral neuropathy. Neurophysiologic studies showed a generalized sensorimotor neuropathy of axonal degeneration type. Examination of a sural nerve biopsy showed a moderately severe axonal neuropathy with loss of large myelinated fibers and unmyelinated axons. There was evidence of slow ongoing degeneration and considerable fiber regeneration. Electron microscopy showed increased numbers of filaments in a few fibers. These findings show resemblances to the nerve changes caused by another acrylic resin, acrylamide. They suggest that the neuropathy may have been caused by 30 years of occupational cutaneous and inhalational exposure to methyl methacrylate monomer since they excluded other recognized causes of neuropathy.

• OSTI ID: 5317773
• Journal Information: Neurology; (United States), Vol. 41:7; ISSN 0028-3878
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
METHYL METHACRYLATE
TOXICITY
ELECTRON MICROSCOPY
ELECTROPHYSIOLOGY
NERVES
NERVOUS SYSTEM DISEASES
OCCUPATIONAL EXPOSURE
PERSONNEL
CARBOXYLIC ACID ESTERS
DISEASES
ESTERS
METHACRYLIC ACID ESTERS
MICROSCOPY
NERVOUS SYSTEM
ORGANIC COMPOUNDS
PHYSIOLOGY
560300* - Chemicals Metabolism & Toxicology