Simple method to quantitate iodine-124 contamination in iodine-123 radiopharmaceuticals
Iodine-123 (/sup 123/I) produced by the /sup 124/Te(p,2n)/sup 123/I reaction contains several percent /sup 124/I radionuclidic contamination at the time of imaging. Since /sup 124/I degrades the quality of the images and causes unnecessary radiation absorbed dose to the patient, it is important to know the amount present in radiopharmaceuticals at the time of administration. A simple approach is described which uses a radionuclide dose calibrator and lead shield. The sample is assayed both shielded and unshielded and the ratio of readings depends uniquely upon the percent /sup 124/I present. The technique can be adopted for any type of dose calibrator, sample container, and Pb shield, but use of the numeric constants reported here should be restricted to the specified equipment.
- Research Organization:
- Medical College of Wisconsin, Milwaukee
- OSTI ID:
- 5313674
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:8
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
PATIENTS
RADIATION DOSES
RADIOPHARMACEUTICALS
CONTAMINATION
CALIBRATION
IMAGES
IODINE 123
IODINE 124
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DOSES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics