Arsenite as the probable active species in the human carcinogenicity of arsenic: Mouse micronucleus assays on Na and K arsenite, orpiment, and Fowler's solution
- ICI Central Toxicology Lab., Cheshire (United Kingdom)
- ICI Colors and Fine Chemicals, Lancashire (United Kingdom)
Sodium arsenite, potassium arsenite, and Fowler's solution (arsenic trioxide dissolved in potassium bicarbonate) are equally active in the mouse bone marrow micronucleus assay ({approximately} 10 mg/kg by IP injection). The natural ore orpiment (principally As{sub 2}S{sub 3}) was inactive despite blood levels of arsenic of 300 to 900 mg/mL in treated mice at 24 hr. Sodium arsenite was active in three strains of mice. It is suggested that the human lung cancer observed among arsenic ore smelters and the skin cancer among people exposed therapeutically to Fowler's solution, have, as their common origin, the genotoxic arsenite ion AsO{sub 2}{sup {minus}}. The difficulty experienced when attempting to demonstrate rodent carcinogenicity for derivatives of arsenic suggests that the bone marrow micronucleus assay may act as a useful assay for potentially carcinogenic arsenic derivatives.
- OSTI ID:
- 5308246
- Journal Information:
- Environmental Health Perspectives; (United States), Vol. 95; ISSN 0091-6765
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ARSENIC COMPOUNDS
BIOLOGICAL EFFECTS
CARCINOGENESIS
EPIDEMIOLOGY
ARSENIC OXIDES
BIOASSAY
BLOOD
CELL NUCLEI
LUNGS
MAN
MICE
NEOPLASMS
SMELTERS
SODIUM COMPOUNDS
ALKALI METAL COMPOUNDS
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CELL CONSTITUENTS
CHALCOGENIDES
DISEASES
MAMMALS
MATERIALS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
PRIMATES
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology