5-Methoxypsoralen, the melanogenic additive in sun-tan preparations, is tumorigenic in mice exposed to 365 nm u. v. radiation
5-Methoxypsoralen (5 MOP), the melanogenic component present in several suntan preparations was synthesized and tested by topical applications in inbred XVII nc/Z albino mice combined with 365 nm irradiation with the aim of establishing the relative carcinogenic activity of this compound, as compared to 8-methoxypsoralen (8 MOP) and psoralen. 85% of the animals developed tumors and 25% had multiple tumors. Additional treatment with 12-O-tetradecanoylphorbol-13-acetate raised the tumor incidence to 100%. Tumors caused by 5 MOP show much longer latent periods than those induced by psoralen and 8 MOP. Most of the tumors were rapidly growing squamous cell carcinomas giving metastases in 20% of the animals. The possible long-term effects that might follow the use of 5 MOP in humans are discussed.
- OSTI ID:
- 5306509
- Journal Information:
- Carcinogenesis (N.Y.); (United States), Vol. 2:2
- Country of Publication:
- United States
- Language:
- English
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CARCINOMAS
RADIOINDUCTION
HETEROCYCLIC COMPOUNDS
RADIOSENSITIVITY EFFECTS
METASTASES
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
COMPARATIVE EVALUATIONS
LATENCY PERIOD
MICE
PHORBOL ESTERS
ULTRAVIOLET RADIATION
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CARCINOGENS
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560151* - Radiation Effects on Animals- Man
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