Cardiopulmonary function and morphologic changes in beagle dogs after multiple lung lavages
This study evaluated the long-term biomedical risks of multiple, massive saline lung lavage using dogs. Risks were assessed using clinical examinations of cardiopulmonary function, thoracic radiographs, auscultation of the chest, body temperature, and hematologic values. Thirty-six dogs given 10 lavages over a 49-day period had no gross lesions at time of necropsy 7 days after the last lavage. Six dogs, followed with clinical examinations after each of 10 lung lavages, had no detectable effects from the lavage except for elevated body temperature and bronchial breathing at 24 hr after some procedures. No gross lesions were found at sacrifice 28 days after the last lavage. The only histologic lesions found were those also found in unlavaged control dogs. Six dogs that were lavaged 10 or more times had normal pulmonary function values for 4 yr after the last lung lavage. No chronic sequelae were found in healthy beagle dogs given 10 or more lung lavages suggesting a minimal long-term risk associated with these procedures.
- Research Organization:
- Inhalation Toxicology Research Inst., Albuquerque, NM
- DOE Contract Number:
- EY-76-C-04-1013
- OSTI ID:
- 5301105
- Journal Information:
- Arch. Environ. Health; (United States), Vol. 35:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CARDIOVASCULAR SYSTEM
BIOLOGICAL FUNCTIONS
MORPHOLOGICAL CHANGES
LAVAGE
BIOLOGICAL EFFECTS
LUNGS
RESPIRATORY SYSTEM
BEAGLES
BIOMEDICAL RADIOGRAPHY
BODY TEMPERATURE
DECONTAMINATION
INJURIES
NECROSIS
SIDE EFFECTS
ANIMALS
BODY
CLEANING
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
RADIOLOGY
VERTEBRATES
550600* - Medicine
551000 - Physiological Systems