Value of positive myocardial technetium-99m-pyrophosphate scintigraphy in the noninvasive diagnosis of cardiac amyloidosis

Journal Article · Thu Apr 01 00:00:00 EST 1982 · Am. Heart J.; (United States)

DOI:https://doi.org/10.1016/0002-8703(82)90331-3· OSTI ID:5300162

Wizenberg, T A; Muz, J; Sohn, Y H; Samlowski, W; Weissler, A M

Ten consecutive patients with tissue-proven amyloidosis, seven of whom presented with congestive heart failure, were found to exhibit intense diffuse uptake of technetium-99m-pyrophosphate (Tc-99m-PYP) on cardiac radionuclide imaging. The patients exhibited echocardiographic and systolic time interval abnormalities suggesting combined restrictive and congestive cardiomyopathic changes. On M-mode echocardiograms, there was symmetrically increased thickness of the interventricular septum and left ventricular (LV) posterior wall in diastole (10 of 10), decreased fractional shortening of the LV minor axis diameter in systole (eight of nine), and decreased percent thickening of the LV minor axis diameter in systole (eight of nine) and LV posterior wall (10 of 10) in systole. Three patients demonstrated enlarged LV end-diastolic diameter. All 10 patients had abnormal PEP/LVET and eight had shortened LVETI. When combined with noninvasive tests of LV performance, positive myocardial pyrophosphate (PYP) scanning provides a new and useful adjunct in the diagnosis of amyloid heart disease.

• Research Organization: Department of Internal Medicine Harper-Grace Hospitals, Detroit, MI
• OSTI ID: 5300162
• Journal Information: Am. Heart J.; (United States), Vol. 103:4
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
CARDIOVASCULAR DISEASES
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PATIENTS
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550601* - Medicine- Unsealed Radionuclides in Diagnostics