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Title: Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma

Abstract

The authors analyzed a t(1;14)(p32;q11) chromosomal translocation in a human lymphohemopoietic stem cell line derived from a patient with acute T-lymphoblastic leukemia. The chromosomal joining on the 1p+ chromosome occurred at the T-cell receptor {delta} diversity (D{delta}{sub 2}) segment, and the reciprocal chromosomal joining on the 14q-chromosome occurred at the T-cell {delta} diversity segment D{delta}{sub 1}. The involvement of {delta} diversity segments at the translocation junction suggests that the translocation occurred during an attempt at D{delta}{sub 1}-D{delta}{sub 2} joining in a stem cell. The segment of chromosome 1 at band p32, adjacent to the chromosomal breakpoint, encodes a transcriptional unit designated TCL5 (T-cell leukemia/lymphoma 5). The differential expression of the TCL5 RNA transcripts in this lymphohemopoietic stem cell line relative to several other T- and B-cell lines suggests that TCL5 gene expression is an integral event in the pathogenesis of the T-cell leukemia. Rearrangement of the TCL5 locus in a human melanoma cell line carrying a del(1p32) further implies that the TCL5 gene may play a role in malignant transformation.

Authors:
; ; ; ; ; ;  [1]
  1. Temple Univ. School of Medicine, Philadelphia, PA (USA)
Publication Date:
OSTI Identifier:
5299676
Resource Type:
Journal Article
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America; (USA)
Additional Journal Information:
Journal Volume: 86:13; Journal ID: ISSN 0027-8424
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CARCINOGENESIS; ETIOLOGY; ONCOGENES; GENE REGULATION; TUMOR CELLS; CHROMOSOMAL ABERRATIONS; DNA SEQUENCING; HETEROCHROMOSOMES; LEUKEMIA; LYMPHOCYTES; MELANOMAS; PATIENTS; PHOSPHORUS 32; STEM CELLS; TRANSCRIPTION; ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CHROMOSOMES; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; DISEASES; GENES; HEMIC DISEASES; IMMUNE SYSTEM DISEASES; ISOTOPES; LEUKOCYTES; LIGHT NUCLEI; MATERIALS; MUTATIONS; NEOPLASMS; NUCLEI; ODD-ODD NUCLEI; PATHOGENESIS; PHOSPHORUS ISOTOPES; RADIOISOTOPES; SOMATIC CELLS; STRUCTURAL CHEMICAL ANALYSIS; 550401* - Genetics- Tracer Techniques

Citation Formats

Finger, L R, Kagan, J, Christopher, G, Kurtzberg, J, Hershfield, M S, Nowell, P C, and Croce, C M. Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. United States: N. p., 1989. Web. doi:10.1073/pnas.86.13.5039.
Finger, L R, Kagan, J, Christopher, G, Kurtzberg, J, Hershfield, M S, Nowell, P C, & Croce, C M. Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. United States. https://doi.org/10.1073/pnas.86.13.5039
Finger, L R, Kagan, J, Christopher, G, Kurtzberg, J, Hershfield, M S, Nowell, P C, and Croce, C M. 1989. "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma". United States. https://doi.org/10.1073/pnas.86.13.5039.
@article{osti_5299676,
title = {Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma},
author = {Finger, L R and Kagan, J and Christopher, G and Kurtzberg, J and Hershfield, M S and Nowell, P C and Croce, C M},
abstractNote = {The authors analyzed a t(1;14)(p32;q11) chromosomal translocation in a human lymphohemopoietic stem cell line derived from a patient with acute T-lymphoblastic leukemia. The chromosomal joining on the 1p+ chromosome occurred at the T-cell receptor {delta} diversity (D{delta}{sub 2}) segment, and the reciprocal chromosomal joining on the 14q-chromosome occurred at the T-cell {delta} diversity segment D{delta}{sub 1}. The involvement of {delta} diversity segments at the translocation junction suggests that the translocation occurred during an attempt at D{delta}{sub 1}-D{delta}{sub 2} joining in a stem cell. The segment of chromosome 1 at band p32, adjacent to the chromosomal breakpoint, encodes a transcriptional unit designated TCL5 (T-cell leukemia/lymphoma 5). The differential expression of the TCL5 RNA transcripts in this lymphohemopoietic stem cell line relative to several other T- and B-cell lines suggests that TCL5 gene expression is an integral event in the pathogenesis of the T-cell leukemia. Rearrangement of the TCL5 locus in a human melanoma cell line carrying a del(1p32) further implies that the TCL5 gene may play a role in malignant transformation.},
doi = {10.1073/pnas.86.13.5039},
url = {https://www.osti.gov/biblio/5299676}, journal = {Proceedings of the National Academy of Sciences of the United States of America; (USA)},
issn = {0027-8424},
number = ,
volume = 86:13,
place = {United States},
year = {Sat Jul 01 00:00:00 EDT 1989},
month = {Sat Jul 01 00:00:00 EDT 1989}
}