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Title: Effect of Withania somnifera on glycosaminoglycan synthesis in carrageenin-induced air pouch granuloma

The effect of W. somnifera on glycosaminoglycan synthesis in the granulation tissue of carrageenin-induced air pouch granuloma was studied. W. somnifera was shown to exert significant inhibitory effect on incorporation of /sup 35/S into the granulation tissue. The uncoupling effect on oxidative phosphorylation (ADP/O ratio reduction) was also observed in the mitochondria of granulation tissue. Further, Mg/sup 2 +/ dependent ATPase activity was found to be influenced by W. somnifera. W. somnifera also reduced the succinate dehydrogenase enzyme activity in the mitochondria of granulation tissue.
Authors:
;
Publication Date:
OSTI Identifier:
5298604
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochem. Med. Metab. Biol.; (United States); Journal Volume: 38:3
Research Org:
Tamil Univ. (India)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ATP-ASE; ENZYME ACTIVITY; GLUCOPROTEINS; BIOSYNTHESIS; OXIDOREDUCTASES; SHRUBS; BIOLOGICAL EFFECTS; ADP; GRANULOMAS; HYDROCORTISONE; INHIBITION; MITOCHONDRIA; PHOSPHORYLATION; RATS; SULFATES; SULFUR 35; ACID ANHYDRASES; ADRENAL HORMONES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOHYDRATES; CELL CONSTITUENTS; CHEMICAL REACTIONS; CORTICOSTEROIDS; DAYS LIVING RADIOISOTOPES; DISEASES; ENZYMES; EVEN-ODD NUCLEI; GLUCOCORTICOIDS; HORMONES; HYDROLASES; HYDROXY COMPOUNDS; ISOTOPES; KETONES; LIGHT NUCLEI; MAMMALS; NEOPLASMS; NUCLEI; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANOIDS; OXYGEN COMPOUNDS; PHOSPHOHYDROLASES; PLANTS; PREGNANES; PROTEINS; RADIOISOTOPES; RODENTS; SACCHARIDES; STEROID HORMONES; STEROIDS; SULFUR COMPOUNDS; SULFUR ISOTOPES; SYNTHESIS; VERTEBRATES 550201* -- Biochemistry-- Tracer Techniques