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Title: Effect of vitamin D on the intestinal absorption of 203Pb and 47Ca in chicks

Abstract

The transfer of 203Pb and/or 47Ca across the intestinal epithelium of the chick was investigated, with emphasis given to the functional role of cholecalciferol (vitamin D-3). 203Pb, after introduction in the intestinal lumen, is rapidly accumulated by the intestinal tissue, and only a fraction of 203Pb is translocated parenterally (absorbed). Cholecalciferol did not significantly affect the accumulation of 203Pb by intestinal tissue but did accelerate 203Pb movement across the basal-lateral membrane. In contrast, cholecalciferol both decreased 47Ca tissue levels and increased 47Ca absorption. In rachitic chicks, the rate of absorption of 203Pb was greater in the distal than in the proximal segments of the intestine; after cholecalciferol repletion, the degree of absorption in al segments was similar, indicting the order of cholecalciferol effectiveness as duodenum greater than or equal to jejunum greater than ileum. An acute dose of 1,25(OH)2D3 to rachitic chicks also enhanced both 203Pb and 47Ca absorption, but the time course and pattern of absorption of these metal cations differed. The time at which the absorption of 203Pb peaked and returned to base-line occurred sooner than for 47Ca. Also the back-flux (blood leads to intestinal lumen) of 47Ca was enhanced by cholecalciferol, whereas no effect on the back-fluxmore » of 203Pb was noted. These studies show that cholecalciferol and 1,25(OH)2D3 affects both the 203Pb and 47Ca absorptive processes, but the nature of these responses are not identical, suggesting differences in the transport path or the macromolecular interactions of these metal ions during the course of absorption, or both.« less

Authors:
;
Publication Date:
Research Org.:
Department of Physiology, New York State College of Veterinary Medicine, Cornell University, Ithaca
OSTI Identifier:
5297754
Resource Type:
Journal Article
Journal Name:
J. Nutr.; (United States)
Additional Journal Information:
Journal Volume: 112:3
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CALCIUM 47; INTESTINAL ABSORPTION; CHOLECALCIFEROL; BIOLOGICAL EFFECTS; LEAD 203; CHICKENS; MEMBRANE TRANSPORT; ABSORPTION; ALKALINE EARTH ISOTOPES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIRDS; CALCIUM ISOTOPES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; FOWL; HEAVY NUCLEI; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LEAD ISOTOPES; NUCLEI; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; UPTAKE; VERTEBRATES; VITAMIN D; VITAMINS; 551001* - Physiological Systems- Tracer Techniques

Citation Formats

Mykkaenen, H M, and Wasserman, R H. Effect of vitamin D on the intestinal absorption of 203Pb and 47Ca in chicks. United States: N. p., 1982. Web.
Mykkaenen, H M, & Wasserman, R H. Effect of vitamin D on the intestinal absorption of 203Pb and 47Ca in chicks. United States.
Mykkaenen, H M, and Wasserman, R H. 1982. "Effect of vitamin D on the intestinal absorption of 203Pb and 47Ca in chicks". United States.
@article{osti_5297754,
title = {Effect of vitamin D on the intestinal absorption of 203Pb and 47Ca in chicks},
author = {Mykkaenen, H M and Wasserman, R H},
abstractNote = {The transfer of 203Pb and/or 47Ca across the intestinal epithelium of the chick was investigated, with emphasis given to the functional role of cholecalciferol (vitamin D-3). 203Pb, after introduction in the intestinal lumen, is rapidly accumulated by the intestinal tissue, and only a fraction of 203Pb is translocated parenterally (absorbed). Cholecalciferol did not significantly affect the accumulation of 203Pb by intestinal tissue but did accelerate 203Pb movement across the basal-lateral membrane. In contrast, cholecalciferol both decreased 47Ca tissue levels and increased 47Ca absorption. In rachitic chicks, the rate of absorption of 203Pb was greater in the distal than in the proximal segments of the intestine; after cholecalciferol repletion, the degree of absorption in al segments was similar, indicting the order of cholecalciferol effectiveness as duodenum greater than or equal to jejunum greater than ileum. An acute dose of 1,25(OH)2D3 to rachitic chicks also enhanced both 203Pb and 47Ca absorption, but the time course and pattern of absorption of these metal cations differed. The time at which the absorption of 203Pb peaked and returned to base-line occurred sooner than for 47Ca. Also the back-flux (blood leads to intestinal lumen) of 47Ca was enhanced by cholecalciferol, whereas no effect on the back-flux of 203Pb was noted. These studies show that cholecalciferol and 1,25(OH)2D3 affects both the 203Pb and 47Ca absorptive processes, but the nature of these responses are not identical, suggesting differences in the transport path or the macromolecular interactions of these metal ions during the course of absorption, or both.},
doi = {},
url = {https://www.osti.gov/biblio/5297754}, journal = {J. Nutr.; (United States)},
number = ,
volume = 112:3,
place = {United States},
year = {Mon Mar 01 00:00:00 EST 1982},
month = {Mon Mar 01 00:00:00 EST 1982}
}