Disturbances in dental development after total body irradiation in bone marrow transplant recipients

Dahlloef, G B; Barr, M; Bolme, P; Modeer, T; Loennqvist, B R; Ringden, O; Heimdahl, A

doi:10.1016/0030-4220(88)90189-2

Title: Disturbances in dental development after total body irradiation in bone marrow transplant recipients

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Abstract

The dental status of 16 children who had been treated with bone marrow transplantation (BMT) for serious bone marrow diseases was followed for up to 6 years. Several types of disturbances in dental development were observed in children who had been conditioned with total body irradiation (TBI) at 10 Gy before BMT. Thus, impaired root development that caused short V-shaped roots was found in all patients, a complete failure of root development and premature apical closure were found in five patients, enamel hypoplasia was observed in four patients, and microdontia was observed in three patients conditioned with TBI. Patients younger than 6 years of age at BMT exhibited the most severe and extensive dental aberrations. The TBI at 10 Gy appeared to be the major cause of the disturbances found.

Authors:: Dahlloef, G B; Barr, M; Bolme, P; Modeer, T; Loennqvist, B R; Ringden, O; Heimdahl, A

Publication Date:: Fri Jan 01 00:00:00 EST 1988

Research Org.:: Karolinska Institute, Stockholm (Sweden)

OSTI Identifier:: 5297435

Resource Type:: Journal Article

Journal Name:: Oral Surg., Oral Med., Oral Pathol.; (United States)

Additional Journal Information:: Journal Volume: 65:1

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE MARROW; TRANSPLANTS; TEETH; BIOLOGICAL RADIATION EFFECTS; AGE DEPENDENCE; CHILDREN; METHOTREXATE; PATIENTS; WHOLE-BODY IRRADIATION; AGE GROUPS; ANIMAL TISSUES; ANTIMETABOLITES; BIOLOGICAL EFFECTS; BODY; DIGESTIVE SYSTEM; DRUGS; EXTERNAL IRRADIATION; HEMATOPOIETIC SYSTEM; IRRADIATION; ORAL CAVITY; ORGANS; RADIATION EFFECTS; TISSUES; 560151* - Radiation Effects on Animals- Man

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                    Dahlloef, G B, Barr, M, Bolme, P, Modeer, T, Loennqvist, B R, Ringden, O, and Heimdahl, A. Disturbances in dental development after total body irradiation in bone marrow transplant recipients.  United States: N. p., 1988. 
        Web.  doi:10.1016/0030-4220(88)90189-2.

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                    Dahlloef, G B, Barr, M, Bolme, P, Modeer, T, Loennqvist, B R, Ringden, O, & Heimdahl, A. Disturbances in dental development after total body irradiation in bone marrow transplant recipients.  United States.  https://doi.org/10.1016/0030-4220(88)90189-2

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                    Dahlloef, G B, Barr, M, Bolme, P, Modeer, T, Loennqvist, B R, Ringden, O, and Heimdahl, A. 1988.  
        "Disturbances in dental development after total body irradiation in bone marrow transplant recipients".  United States.  https://doi.org/10.1016/0030-4220(88)90189-2.

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@article{osti_5297435,

  title        = {Disturbances in dental development after total body irradiation in bone marrow transplant recipients},

  author       = {Dahlloef, G B and Barr, M and Bolme, P and Modeer, T and Loennqvist, B R and Ringden, O and Heimdahl, A},

  abstractNote = {The dental status of 16 children who had been treated with bone marrow transplantation (BMT) for serious bone marrow diseases was followed for up to 6 years. Several types of disturbances in dental development were observed in children who had been conditioned with total body irradiation (TBI) at 10 Gy before BMT. Thus, impaired root development that caused short V-shaped roots was found in all patients, a complete failure of root development and premature apical closure were found in five patients, enamel hypoplasia was observed in four patients, and microdontia was observed in three patients conditioned with TBI. Patients younger than 6 years of age at BMT exhibited the most severe and extensive dental aberrations. The TBI at 10 Gy appeared to be the major cause of the disturbances found.},

  doi          = {10.1016/0030-4220(88)90189-2},

  url          = {https://www.osti.gov/biblio/5297435},
  journal      = {Oral Surg., Oral Med., Oral Pathol.; (United States)},
number       = ,

  volume       = 65:1,

  place        = {United States},

  year         = {Fri Jan 01 00:00:00 EST 1988},

  month        = {Fri Jan 01 00:00:00 EST 1988}

}

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