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Title: Immunization of mice with Trypanosoma rhodesiense exposed to ultraviolet irradiation

Exposure time of Trypanosoma rhodesiense as short as 1 minute to ultraviolet (uv) light prevents the organisms from causing infection. Live trypanosome challenge of mice immunized with uv-irradiated trypanosomes results in sterile immunity. This allows a method for the induction of protective immunity to experimental trypanosomiasis which can be performed in most laboratories using uv germicidal lamps found in sterile hoods.
Authors:
;
Publication Date:
OSTI Identifier:
5296312
Resource Type:
Journal Article
Resource Relation:
Journal Name: Am. J. Trop. Med. Hyg.; (United States); Journal Volume: 30:6
Research Org:
Univ. of New Mexico School of Medicine, Albuquerque
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; TRYPANOSOMA; BIOLOGICAL RADIATION EFFECTS; TRYPANOSOMIASIS; VACCINES; IMMUNITY; INFECTIVITY; MICE; ULTRAVIOLET RADIATION; ANIMALS; BIOLOGICAL EFFECTS; DISEASES; ELECTROMAGNETIC RADIATION; INFECTIOUS DISEASES; MAMMALS; MASTIGOPHORA; PARASITES; PARASITIC DISEASES; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES 560134* -- Radiation Effects on Microorganisms-- Vaccine Preparation & Other Applications-- (-1987)