Nasal mucosal blood flow after intranasal allergen challenge
The nasal mucosal blood flow in patients with allergic rhinitis was determined at nasal allergen challenges with the /sup 133/Xenon washout method. Determinations were made in 12 subjects before and 15 minutes after challenge with diluent and increasing doses of allergen. The time course was followed in eight subjects by means of repeated measurements during 1 hour after a single allergen dose. Finally, the blood flow was measured after unilateral allergen challenge in the contralateral nasal cavity. A dose-dependent decrease in blood flow was found after nasal challenge with increasing doses of allergens, whereas challenge with diluent alone did not induce any changes. The highest allergen dose, which also induced pronounced nasal symptoms, resulted in a decrease in blood flow of 25% (p less than 0.001). The time-course study demonstrated a maximum decrease in blood flow 10 to 20 minutes after challenge and then a gradual return to baseline. Unilateral allergen challenge resulted in a decrease in blood flow in the contralateral, unchallenged nasal cavity, suggesting that part of the allergen-induced changes in blood flow were reflex mediated.
- Research Organization:
- Gothenburg Univ. (Sweden)
- OSTI ID:
- 5289704
- Journal Information:
- J. Allergy Clin. Immunol.; (United States), Vol. 81:3
- Country of Publication:
- United States
- Language:
- English
Similar Records
Studies on air pollution: Effects of nitrogen dioxide on airway caliber and reactivity in asthmatic subjects; effects of nitrogen dioxide on lung lymphocytes and macrophage products in healthy subjects; nasal and bronchial effects of sulfur dioxide in asthmatic subjects. Final report, 26 June 1987-26 November 1988
House-dust mite allergen and ozone exposure decreases histamine H3 receptors in the brainstem respiratory nuclei
Related Subjects
MUCOUS MEMBRANES
BLOOD FLOW
NOSE
ALLERGY
DOSE-RESPONSE RELATIONSHIPS
PATHOGENESIS
PATIENTS
TRACER TECHNIQUES
XENON 133
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
FACE
HEAD
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MEMBRANES
NUCLEI
PATHOLOGICAL CHANGES
RADIOISOTOPES
RESPIRATORY SYSTEM
XENON ISOTOPES
550901* - Pathology- Tracer Techniques