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Title: Effects of ventromedial and lateral hypothalamic stimulation on chemically-induced liver injury in rats

The effects of hypothalamic stimulation on experimental liver injury induced by carbon tetrachloride (CCL/sub 4/) or dimethylnitrosamine (DMN) were studied in rats, by measuring plasma alanine amino-transferase (ALT) activity as an index of acute liver injury. Electrical stimulation of the ventromedial hypothalamus (VHM) in CCl/sub 4/-treated rats caused a marked increase in plasma ALT activity, accompanied by a significant decrease in ALT activity in the liver, although CCl4 treatment alone had no significant effect on plasma ALT activity. A similar effect of VHM stimulation on plasma ALT activity was observed in rats treated with DMN, another hepatotoxic chemical. No such exaggerated effect of VMH stimulation on plasma ALT activity was observed after stimulation of the lateral hypothalamic area (LH). Surgical sympathetic denervation of the liver greatly suppressed the increase in plasma ALT activity after CCl/sub 4/ injection and VMH stimulation. Measurement of regional blood flow indicated that VMH stimulation did not produce a significant change in blood flow to the liver. These results suggest that the VMH is involved in the progress of chemically-induced liver injury through activation of the sympathetic nerve, possibly by affecting liver metabolism more than the blood flow change to the liver.
Authors:
;
Publication Date:
OSTI Identifier:
5284506
Resource Type:
Journal Article
Resource Relation:
Journal Name: Life Sci.; (United States); Journal Volume: 42:19
Research Org:
Ehime Univ. School of Medicine (Japan)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; AMINOTRANSFERASES; ENZYME ACTIVITY; CARBON TETRACHLORIDE; TOXICITY; HYPOTHALAMUS; BIOLOGICAL FUNCTIONS; LIVER; BLOOD FLOW; PATHOLOGICAL CHANGES; NITROSAMINES; NERVES; RATS; AMINES; ANIMALS; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; CHLORINATED ALIPHATIC HYDROCARBONS; DIGESTIVE SYSTEM; ENZYMES; FUNCTIONS; GLANDS; HALOGENATED ALIPHATIC HYDROCARBONS; MAMMALS; NERVOUS SYSTEM; NITROGEN TRANSFERASES; NITROSO COMPOUNDS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RODENTS; TRANSFERASES; VERTEBRATES 560300* -- Chemicals Metabolism & Toxicology