Cardiac and pulmonary anaphylaxis in guinea pigs and rabbits induced by glycoprotein isolated from tobacco leaves and cigarette smoke condensate
Cigarette smoking is a major risk factor for heart attack. The pathologic mechanisms responsible for this association are obscure. It has been reported that approximately one-third of human volunteers, smokers and nonsmokers, exhibit immediate cutaneous hypersensitivity to a glycoprotein antigen (TGP) purified from cured tobacco leaves and present in cigarette smoke. It is also known that the heart is a primary target organ for anaphylactic reaction in many animals, including primates. In experiments described herein anaphylaxis was induced in the isolated hearts and lungs of rabbits and guinea pigs previously sensitized by immunization with TGP and challenged with TGP isolated from either tobacco leaf or cigarette smoke condensate. Cardiac anaphylaxis was characterized by sinus tachycardia, decreased contractility, decreased coronary perfusion accompanied by hypoxic electrocardiographic changes, and a variety of rhythm disturbances, including idioventricular tachyarrhythmias. These observations suggest that allergic reactions to tobacco constituents may initiate cardiac arrhythmia and sudden death in some smokers and may, in part, underly the association between cigarette smoking and heart attack.
- Research Organization:
- Cornell University Medical College, New York
- OSTI ID:
- 5282271
- Journal Information:
- Am. J. Pathol.; (United States), Vol. 106:3
- Country of Publication:
- United States
- Language:
- English
Similar Records
Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts
Cigarette use and the estimation of lung cancer attributable to radon in the United States
Related Subjects
GLUCOPROTEINS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
HEART
ANAPHYLAXIS
LUNGS
TOBACCO SMOKES
ELECTROCARDIOGRAMS
GUINEA PIGS
RABBITS
TOBACCO
AEROSOLS
ANIMALS
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
CHEMISTRY
COLLOIDS
DIAGRAMS
DISPERSIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SACCHARIDES
SMOKES
SOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)