skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Respiratory involvement and immune status in Yusho patients

Abstract

Clinical and experimental studies on respiratory involvement and alterations in immune status were carried out. Respiratory distress occurring in these patients has improved gradually for 14 years but still remains. Copious expectoration at an early stage of the disease may be related to the fact that a number of discrete polychlorinated biphenyls (PCBs) are distributed throughout the lung parenchyma. For accumulation in the bronchial mucosa, structural requirements and specific dose dependence of PCBs have been clearly shown; however, pathological and physiological studies have indicated that respiratory involvement in Yusho is mainly small airway disease that may be caused by involvement of cellular component (Clara cells) in bronchioles and/or associated infection. Respiratory distress is often exacerbated by viral or bacterial infection. Changes in the immune status in PCB and polychlorinated dibenzofuran (PCDF) poisoning are as follows: IgA and IgM in the serum are decreased at an early stage of the disease and then return to normal; suppression of cellular immunity was reported in Taiwanese patients and some may remain in the later stages of the disease, as shown in our patients. PCDFs now appear to be the main causal agents in Yusho. Rats given PCDFs showed necrosis of the Clara cellsmore » in bronchioles and marked thymus atrophy, while few such changes were noted in rats given PCBs. Therefore, further examination is needed for the difference of the toxic effects between two compounds.« less

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Kyushu Univ., Fukuoka, Japan
OSTI Identifier:
5274915
Resource Type:
Journal Article
Journal Name:
Environ. Health Perspect.; (United States)
Additional Journal Information:
Journal Volume: 59
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHLORINATED AROMATIC HYDROCARBONS; BIOLOGICAL EFFECTS; LUNGS; PATHOLOGICAL CHANGES; IMMUNOLOGY; IMMUNOSUPPRESSION; JAPAN; PATIENTS; RATS; ANIMALS; AROMATICS; ASIA; BODY; HALOGENATED AROMATIC HYDROCARBONS; MAMMALS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANS; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987); 560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Nakanishi, Y, Shigematsu, N, Kurita, Y, Matsuba, K, Kanegae, H, Ishimaru, S, and Kawazoe, Y. Respiratory involvement and immune status in Yusho patients. United States: N. p., 1985. Web. doi:10.2307/3429870.
Nakanishi, Y, Shigematsu, N, Kurita, Y, Matsuba, K, Kanegae, H, Ishimaru, S, & Kawazoe, Y. Respiratory involvement and immune status in Yusho patients. United States. https://doi.org/10.2307/3429870
Nakanishi, Y, Shigematsu, N, Kurita, Y, Matsuba, K, Kanegae, H, Ishimaru, S, and Kawazoe, Y. 1985. "Respiratory involvement and immune status in Yusho patients". United States. https://doi.org/10.2307/3429870.
@article{osti_5274915,
title = {Respiratory involvement and immune status in Yusho patients},
author = {Nakanishi, Y and Shigematsu, N and Kurita, Y and Matsuba, K and Kanegae, H and Ishimaru, S and Kawazoe, Y},
abstractNote = {Clinical and experimental studies on respiratory involvement and alterations in immune status were carried out. Respiratory distress occurring in these patients has improved gradually for 14 years but still remains. Copious expectoration at an early stage of the disease may be related to the fact that a number of discrete polychlorinated biphenyls (PCBs) are distributed throughout the lung parenchyma. For accumulation in the bronchial mucosa, structural requirements and specific dose dependence of PCBs have been clearly shown; however, pathological and physiological studies have indicated that respiratory involvement in Yusho is mainly small airway disease that may be caused by involvement of cellular component (Clara cells) in bronchioles and/or associated infection. Respiratory distress is often exacerbated by viral or bacterial infection. Changes in the immune status in PCB and polychlorinated dibenzofuran (PCDF) poisoning are as follows: IgA and IgM in the serum are decreased at an early stage of the disease and then return to normal; suppression of cellular immunity was reported in Taiwanese patients and some may remain in the later stages of the disease, as shown in our patients. PCDFs now appear to be the main causal agents in Yusho. Rats given PCDFs showed necrosis of the Clara cells in bronchioles and marked thymus atrophy, while few such changes were noted in rats given PCBs. Therefore, further examination is needed for the difference of the toxic effects between two compounds.},
doi = {10.2307/3429870},
url = {https://www.osti.gov/biblio/5274915}, journal = {Environ. Health Perspect.; (United States)},
number = ,
volume = 59,
place = {United States},
year = {Fri Feb 01 00:00:00 EST 1985},
month = {Fri Feb 01 00:00:00 EST 1985}
}