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Title: Bromocryptine prevents the decline in tuberoinfundibular neuronal release of dopamine after removal of chronic estrogen treatment

Prolonged exposure to estradiol 17-..beta.. (E/sub 2/) in rats has been shown to decrease dopamine (DA) synthesis in and release from tuberoinfundibular dopaminergic (TIDA) neurons in Fischer 344 rats. The objective of the present study was to determine whether inhibition of the E/sub 2/-induced increase in anterior pituitary (AP) weight and prolactin (PRL) secretion by concomitant administration of the dopaminergic agonist, bromocryptine, could prevent the decrease in TIDA neuronal function produced by chronic E/sub 2/ administration. TIDA neuronal function was evaluated by in vitro superfusion and electrical stimulation of median eminence (ME) tissue after allowing for accumulation of (/sup 3/H) dopamine (DA). The effect of chronic E/sub 2/ and/or bromocryptine treatment on catecholamine content in tuberohypophyseal neurons in the neurointermediate lobe was also measured to determine whether increased pituitary size possibly damaged the tuberohypophyseal neurons.
Authors:
;
Publication Date:
OSTI Identifier:
5272055
Resource Type:
Journal Article
Resource Relation:
Journal Name: Proc. Soc. Exp. Biol. Med.; (United States); Journal Volume: 186:2
Research Org:
Michigan State Univ., East Lansing (USA)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; DOPAMINE; BIOSYNTHESIS; ENZYME INHIBITORS; BIOLOGICAL EFFECTS; ESTRADIOL; BIOLOGICAL FUNCTIONS; CATECHOLAMINES; CHRONIC EXPOSURE; INHIBITION; LTH; NERVE CELLS; PITUITARY GLAND; TRACER TECHNIQUES; TRITIUM COMPOUNDS; AMINES; ANIMAL CELLS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BODY; CARDIOTONICS; CARDIOVASCULAR AGENTS; DRUGS; ENDOCRINE GLANDS; ESTRANES; ESTROGENS; FUNCTIONS; GLANDS; GONADOTROPINS; HORMONES; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PHENOLS; PITUITARY HORMONES; POLYPHENOLS; SOMATIC CELLS; STEROID HORMONES; STEROIDS; SYMPATHOMIMETICS; SYNTHESIS 550201* -- Biochemistry-- Tracer Techniques