Systemic toxicity of coal liquefaction products: results of a 14-day dermal exposure
Increasing energy demands, coupled with rising prices and an unstable world oil market have stimulated international interest in developing alternative sources of fuel. Direct coal liquefaction processes (CLP) hold great potential for Canada because of its large coal reserves. The conversion of coal to liquefied fuels results in many fractions of differing hydrocarbon content and includes many toxic substances such as polynuclear aromatic hydrocarbons. Since the major route of occupational exposure would be via the dermal route and since studies of systemic toxicity following dermal exposure are lacking, preliminary studies were conducted on the toxicity of SRC-II process coal liquefaction products applied dermally to the rat. Samples of the light (L), intermediate (I), and heavy, (H) fractions produced during the SRC-II coal liquefaction process, were kindly provided by the Sandwell Beak Research Group (Mississauga, Ontario, Canada). Diesel Fuel (D) was purchased from an Esso Gasoline Station. Male and female Sprague-Dawley rats weighing 200 +/- 25 grams were used.
- Research Organization:
- Health and Welfare Canada, Ottawa, Ontario (Canada)
- OSTI ID:
- 5270030
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 40:3
- Country of Publication:
- United States
- Language:
- English
Similar Records
Dermal absorption and disposition of 1,3-diphenylguanidine in rats
Developmental toxicity study in rats exposed dermally to clarified slurry oil for a limited period of gestation
Related Subjects
COAL LIQUIDS
SKIN ABSORPTION
TOXICITY
BLOOD CHEMISTRY
BONE MARROW
BRAIN
COAL LIQUEFACTION
FEMALES
HEART
LIVER
LUNGS
MALES
RATS
SKIN
SRC-II PROCESS
TISSUE DISTRIBUTION
ABSORPTION
ANIMAL TISSUES
ANIMALS
BODY
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
DISTRIBUTION
FLUIDS
GLANDS
HEMATOPOIETIC SYSTEM
LIQUEFACTION
LIQUIDS
MAMMALS
NERVOUS SYSTEM
ORGANS
RESPIRATORY SYSTEM
RODENTS
THERMOCHEMICAL PROCESSES
TISSUES
UPTAKE
VERTEBRATES
016000* - Coal
Lignite
& Peat- Health & Safety