Differential accumulation of lead by soft tissues of rabbit

Journal Article · Sat Aug 01 00:00:00 EDT 1987 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01689426· OSTI ID:5269597

Villarreal-Trevino, C M; Villegas-Navarro, A

In studies on retention of lead by soft tissues, it is reported that, in acute and chronic intoxications, the concentration of Pb decrease in the following order: liver, kidney, heart and brain. The liver contains more lead than the other soft tissues; this might be due to the volume of blood that stays within the organ. Several parameters like age, temperature, perfusion, vascularity and residual blood volume could be important factors in the movement and differential accumulation of lead in blood and tissues. However, these parameters do not completely explain the quantitative differences in the retention of Pb between organs, and it is possible that other factors like the dose and the time between the administration of lead and the killing (exposure time), would have considerable importance in this process that so far has not been satisfactorily explained. The relationships between the size of a dose of lead given intravenously and the retention of this metal by some organs, as well as the effect of the duration of exposure of an intravenously administered dose of lead on accumulation were studied in this work. The possible relationships between accumulation and the values reported for perfusion and residual blood volumes were also studied.

• Research Organization: Unidad de Investigations Biomedica del Noreste del Instituto Mexicano del Seguro Social, Nuevon Leon (Mexico)
• OSTI ID: 5269597
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 39:2
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LEAD COMPOUNDS
INTRAVENOUS INJECTION
UPTAKE
ABSORPTION SPECTROSCOPY
BLOOD CHEMISTRY
BRAIN
HEART
KIDNEYS
LIVER
RABBITS
ANIMALS
BODY
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
GLANDS
INJECTION
INTAKE
MAMMALS
NERVOUS SYSTEM
ORGANS
SPECTROSCOPY
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology