Tests for induction of presumed dominant-lethal effects in female mice
Abstract
The two carcinogens, benzo(a)pyrene (BP), and 2-acetylaminofluorene (2AAF), and their respective noncarcinogenic analogs, pyrene (PYR) and 4-acetylaminofluorene (4AAF), were tested for induction of presumed dominant-lethal effects in female mice. Each chemical was administered as a single intraperitoneal injection using the maximum dose that could be given as limited either by toxicity or solubility. The study was conducted in at least two stocks of females and the induction of presumed dominant-lethal response was determined in oocytes in maturing follicles. Among the four compounds studied, only BP induced clear-cut presumed dominant-lethal effects. In addition, it had cytotoxic effects on the oocytes resulting in marked reduction in the reproductive performance of treated females. 11 refs., 1 fig., 4 tabs.
- Authors:
- Publication Date:
- Research Org.:
- Oak Ridge National Lab., TN (USA)
- OSTI Identifier:
- 5267970
- Report Number(s):
- CONF-8505178-2
ON: DE85016961
- DOE Contract Number:
- AC05-84OR21400
- Resource Type:
- Conference
- Resource Relation:
- Conference: Collaborative study on short-term tests for genotoxicity and carcinogenicity, Cap d'Adge, France, 14 May 1985
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ACETYLAMINOFLUORENES; GENETIC EFFECTS; BENZOPYRENE; PYRENE; CARCINOGENS; DOMINANT MUTATIONS; FEMALES; LETHAL MUTATIONS; MICE; OOGONIA; ANIMALS; AROMATICS; BIOLOGICAL EFFECTS; CONDENSED AROMATICS; GERM CELLS; HYDROCARBONS; MAMMALS; MUTATIONS; ORGANIC COMPOUNDS; RODENTS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
Citation Formats
Generoso, W M, Cain, K T, Hughes, L A, and Braden, P W. Tests for induction of presumed dominant-lethal effects in female mice. United States: N. p., 1985.
Web.
Generoso, W M, Cain, K T, Hughes, L A, & Braden, P W. Tests for induction of presumed dominant-lethal effects in female mice. United States.
Generoso, W M, Cain, K T, Hughes, L A, and Braden, P W. 1985.
"Tests for induction of presumed dominant-lethal effects in female mice". United States.
@article{osti_5267970,
title = {Tests for induction of presumed dominant-lethal effects in female mice},
author = {Generoso, W M and Cain, K T and Hughes, L A and Braden, P W},
abstractNote = {The two carcinogens, benzo(a)pyrene (BP), and 2-acetylaminofluorene (2AAF), and their respective noncarcinogenic analogs, pyrene (PYR) and 4-acetylaminofluorene (4AAF), were tested for induction of presumed dominant-lethal effects in female mice. Each chemical was administered as a single intraperitoneal injection using the maximum dose that could be given as limited either by toxicity or solubility. The study was conducted in at least two stocks of females and the induction of presumed dominant-lethal response was determined in oocytes in maturing follicles. Among the four compounds studied, only BP induced clear-cut presumed dominant-lethal effects. In addition, it had cytotoxic effects on the oocytes resulting in marked reduction in the reproductive performance of treated females. 11 refs., 1 fig., 4 tabs.},
doi = {},
url = {https://www.osti.gov/biblio/5267970},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1985},
month = {Tue Jan 01 00:00:00 EST 1985}
}