Exposure of the cat limb to @5C for 5 hours increases capillary permeability

Conference · Mon Mar 11 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5267324

Zhang, J X; Porter, L P; Wolf, M B ^[1]

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1. Univ. of South Carolina, Columbia (United States)

The authors previous study showed that 1 hr exposure to {approximately}5C temperatures did not decrease the solvent drag reflection coefficient ({sigma}{sub f}) for total plasma proteins in the isolated, constant-flow perfused cat hind limb. The present study determined if 5 hrs of cold exposure could increase permeability (decrease {sigma}{sub f}). {sigma}{sub f} was measured with their IMB method after lowering limb temperature to 3-6C by cooling the perfusing blood and the ambient air. To prevent edema at this low temperature, venous pressure had to be lowered to just above venous collapse and flow to {lt}2 ml/min/100g. 1 hr exposure to {approximately}5C did not reduce {sigma}{sub f} from the 37C control, but 5 hrs of exposure at {approximately}5C significantly reduced {sigma}{sub f} from 0.87 to 0.69. Hence, 5 hrs of perfusion at these low temperatures can cause a non-freezing cold injury with an increase in capillary permeability and edema formation. Also, the edema is enhanced by an increase in capillary hydrostatic pressure secondary to a venous resistance increase.

• OSTI ID: 5267324
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CAPILLARIES
PERMEABILITY
CATS
HYPOTHERMIA
BIOLOGICAL EFFECTS
BLOOD FLOW
BLOOD PRESSURE
EDEMA
LIMBS
METABOLISM
TEMPERATURE EFFECTS
ANIMALS
BLOOD VESSELS
BODY
BODY AREAS
BODY TEMPERATURE
CARDIOVASCULAR SYSTEM
MAMMALS
ORGANS
PATHOLOGICAL CHANGES
SYMPTOMS
VERTEBRATES
560200* - Thermal Effects