Incorporating tracer-tracee differences into models to improve accuracy

Journal Article · Wed May 01 00:00:00 EDT 1991 · JPEN, Journal of Parenteral and Enteral Nutrition; (United States)

DOI:https://doi.org/10.1177/014860719101500364S· OSTI ID:5266111

Schoeller, D A ^[1]

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1. University of Chicago, Illinois (USA)

The ideal tracer for metabolic studies is one that behaves exactly like the tracee. Compounds labeled with isotopes come the closest to this ideal because they are chemically identical to the tracee except for the substitution of a stable or radioisotope at one or more positions. Even this substitution, however, can introduce a difference in metabolism that may be quantitatively important with regard to the development of the mathematical model used to interpret the kinetic data. The doubly labeled water method for the measurement of carbon dioxide production and hence energy expenditure in free-living subjects is a good example of how differences between the metabolism of the tracers and the tracee can influence the accuracy of the carbon dioxide production rate determined from the kinetic data.

• OSTI ID: 5266111
• Journal Information: JPEN, Journal of Parenteral and Enteral Nutrition; (United States), Vol. 15:3; ISSN 0148-6071
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
METABOLISM
MATHEMATICAL MODELS
ACCURACY
CARBON DIOXIDE
DEUTERIUM
DOUBLE LABELLING
MAN
OXYGEN ISOTOPES
TRACER TECHNIQUES
WATER
ANIMALS
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
HYDROGEN COMPOUNDS
HYDROGEN ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLING
LIGHT NUCLEI
MAMMALS
NUCLEI
ODD-ODD NUCLEI
OXIDES
OXYGEN COMPOUNDS
PRIMATES
STABLE ISOTOPES
VERTEBRATES
550501* - Metabolism- Tracer Techniques