Intraprostatic injection of neutralized zinc in rats

Conference · Mon Mar 11 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5264568

Fahim, M S; Wang, M; Sutcu, M F; Fahim, Z; Safron, J A; Ganjam, V K ^[1]

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1. Univ. of Missouri, Columbia (United States) Xian Medical University (China)

Zinc has been implicated in steroid endocrinology of the prostate gland. The conversion of testosterone to dihydrotestosterone (DHT) by 5{alpha}-reductase enzyme is believed to express androgenic responses in the prostate. To note the effect of neutralized zinc on the prostate, 50 sexually mature rats, weighing 325 {plus minus} 20 grams, were divided into 5 groups as follows: (1) control, (2) sham, (3) castrated, (4) injected intraprostatically with 10 mg. neutralized zinc, and (5) injected intraprostatically with 20 mg. neutralized zinc. Results in the treated groups indicated significant reduction of prostate weights, 12% and 53% and histologically normal prostate; no significant change in weight and histological structure of testes, epididymides, and seminal vesicles; significant reduction in 5{alpha}-reductase activity and total protein and DNA concentrations in prostate tissue; and no significant effect on progeny of treated animals. These results suggest that direct application of neutralized zinc to the prostate offers a new modality for treatment of prostatitis without affecting spermatogenesis and testosterone production.

• OSTI ID: 5264568
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
PROSTATE
SENSITIVITY
ZINC
BIOLOGICAL EFFECTS
ENDOCRINE DISEASES
METABOLISM
OXIDOREDUCTASES
RATS
TESTOSTERONE
ANDROGENS
ANDROSTANES
ANIMALS
BODY
DISEASES
ELEMENTS
ENZYMES
GLANDS
HORMONES
HYDROXY COMPOUNDS
KETONES
MALE GENITALS
MAMMALS
METALS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RODENTS
STEROID HORMONES
STEROIDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology