Neuroblastoma: A neurochemical approach

Journal Article · Mon Jul 01 00:00:00 EDT 1991 · Journal of Child Neurology; (United States)

DOI:https://doi.org/10.1177/088307389100600303· OSTI ID:5263737

Schor, N F ^[1]

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1. Children's Hospital of Pittsburgh, PA (USA)

Neuroblastoma is among the most common malignancies of childhood. Despite greatly improved therapy for some pediatric tumors, the prognosis for children with metastatic neuroblastoma has not changed significantly in the past 10 years. With conventional chemotherapy, radiation therapy, and surgery, children with metastatic neuroblastoma have a 20% long-term survival rate. The authors describe here approaches to neuroblastoma that target its neuronal characteristics. On the one hand, the neurotransmitter receptors on the surface of the neuroblastoma cells and, on the other hand, specific isozymes that distinguish neuroblastoma cells from their normal counterparts are the focus of these experimental therapies. In the former case, specificity for tumor cells is effected by (1) selective protection of normal neuronal elements from toxicity, or (2) selective potentiation of toxicity for neural tumor cells. It is hoped that these strategies will be generalizable to other neural crest-derived tumors. 32 references.

• OSTI ID: 5263737
• Journal Information: Journal of Child Neurology; (United States), Vol. 6:3; ISSN 0883-0738
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
NEOPLASMS
RADIOTHERAPY
NERVOUS SYSTEM
CHILDREN
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PATIENTS
SURGERY
SURVIVAL CURVES
AGE GROUPS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
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MAMMALS
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NEUROREGULATORS
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RODENTS
SYMPATHOMIMETICS
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550603* - Medicine- External Radiation in Therapy- (1980-)