Radiotherapeutic management of optic nerve gliomas in children

Conference · Tue Jan 01 00:00:00 EST 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5262656

Danoff, B F; Kramer, S; Thompson, N

Optic nerve gliomas represent one to five percent of all intracranial tumors in children. The management of these tumors remains controversial. From 1956 to 1977, 18 children with optic nerve gliomas were treated at Thomas Jefferson University Hospital using external beam radiotherapy. All children presented with decreased visual acuity and five of eighteen were blind in one eye. No patient was found to have involvement of a single optic nerve. in eight patients, the chiasm was involved, in ten patients, tumor had extended to the frontal lobes and/or hypothalamus. Initial surgical management included biopsy only in seven patients, inspection of tumor in two patients and partial excision in seven patients. Two patients were treated with radiotherapy based on radiological findings. A tumor dose of 5000 to 6000 rad was given in 5.5 to 6.5 weeks. Stabilization of visual impairment or improvement in vision was noted in 78 percent of patients who were evaluable. The ten year survival was 73 percent. Radiological evidence of tumor regression will be presented. It is our impression that radiotherapy is indicated in the treatment of children with optic nerve gliomas who have poor prognostic signs (i.e., chiasmal and/or hypothalamic involvement and progressive visual loss).

• Research Organization: Thomas Jefferson Univ. Hospital, Philadelphia, PA
• OSTI ID: 5262656
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 6:1; Conference: American Society of Therapeutic Radiologists annual meeting, Los Angeles, CA, USA, 31 Oct 1978
• Country of Publication: United States
• Language: English

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