Modification of sympathetic neuronal function in the rat tail artery by dietary lipid treatment
The effect of dietary lipid treatment on sympathetic neuronal function was examined in isolated perfused tail arteries of adult rats. The hypothesis that dietary manipulations alter the lipid environment of receptor proteins which may result in the perturbation of specific membrane-associated processes that regulate peripheral adrenergic neurotransmission in the vasculature was the basis for this investigation. In the present study, rats were fed semisynthetic diets enriched in either 16% coconut oil (saturated fat) or 16% sunflower oil (unsaturated fat). The field stimulation-evoked release of endogenous norepinephrine and total /sup 3/H was decreased significantly in rats receiving the coconut oil diet when compared to either sunflower oil- or standard lab chow-fed rats. Norepinephrine content in artery segments from coconut oil-treated rats was significantly higher compared to either sunflower oil- or standard lab chow-fed rats. Tail arteries from rats receiving the coconut oil diet displayed significantly lower perfusion pressure responses to nerve stimulation at all frequencies tested when compared to the sunflower oil- or standard lab chow-fed rats. Vasoconstrictor responses of perfused tail arteries exposed to exogenous norepinephrine resulted in an EC50 for norepinephrine that was not changed by the dietary treatment, but adult rats receiving the sunflower oil diet displayed a significantly greater maximum response to exogenous norepinephrine (10(-5) M) compared to arteries from either coconut oil- or standard lab chow-fed rats.
- Research Organization:
- Univ. of Kansas, Lawrence
- OSTI ID:
- 5254002
- Journal Information:
- J. Pharmacol. Exp. Ther.; (United States), Vol. 3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LIPIDS
BIOLOGICAL EFFECTS
RECEPTORS
ARTERIES
AUTONOMIC NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DIET
FATS
IN VITRO
MUSCLES
NERVES
NORADRENALINE
OILS
PERFUSED TISSUES
PREGNANCY
RATS
TRITIUM COMPOUNDS
VASOCONSTRICTION
ADRENAL HORMONES
ANIMAL TISSUES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BLOOD VESSELS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
DRUGS
HORMONES
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
TISSUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques