Multiple daily fractionation (MDF) radiotherapy in association with hyperthermia and/or misonidazole: experimental and clincial results. [4. 5 MeV photons]
- Instituto Medico Scientifico, Rome, Italy
Several modalities involving a Multiple Daily Fractionation (MDF) course in combination with hyperthermia and/or the hypoxic sensitizer misonidazole were tested on a mouse tumor system and then applied, with the proper sequencing, to a group of patients with multiple neck node metastases from H and N cancers. Different lesions of the same patients underwent different modalities. The clinical results indicate the effectiveness, in respect to a historical series of patients treated with conventional fractionation, of either MDF alone, or MDF + hyperthermia, or MDF + misonidazole, or MDF + hyperthermia + misonidazole. The latter modality appears to be possibly the most effective at inducing a complete local tumor response lasting longer in time. The pharmacology of misonidazole was monitored in the patients to avoid undesired excessive drug plasma level. No neurological symptoms were observed. Oropharyngeal mucositis was observed only in patients treated with misonidazole and radiation through two cross-firing portals. The problem of selecting individual patients for a particular modality is discussed.
- OSTI ID:
- 5246755
- Journal Information:
- Cancer; (United States), Vol. 45:11; Conference: 61. annual meeting of the American Radium Society, Los Angeles, CA, USA, 4 Mar 1979
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
FRACTIONATED IRRADIATION
RADIOSENSITIVITY EFFECTS
HYPERTHERMIA
INFLAMMATION
RADIOINDUCTION
MUCOUS MEMBRANES
EARLY RADIATION EFFECTS
ORAL CAVITY
PHARYNX
RADIOSENSITIZERS
RADIOTHERAPY
SIDE EFFECTS
LOCAL IRRADIATION
METASTASES
MEV RANGE 01-10
NECK
PATIENTS
PHOTONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
BODY TEMPERATURE
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELEMENTARY PARTICLES
ENERGY RANGE
IRRADIATION
MASSLESS PARTICLES
MEDICINE
MEV RANGE
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOLOGY
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)