Extract of feverfew inhibits interactions of human platelets with collagen substrates

Journal Article · Tue Dec 01 00:00:00 EST 1987 · Thromb. Res.; (United States)

DOI:https://doi.org/10.1016/0049-3848(87)90383-5· OSTI ID:5243275

Loesche, W M; Mazurov, A V; Heptinstall, S; Groenewegen, W A; Repin, V S; Till, U

The interaction of platelets with surfaces coated with collagens of type III (C III) or IV (C IV) has been studied by measuring the deposition of /sup 51/Cr-labeled platelets and by scanning electron microscopy (SEM). Experiments were performed using platelet-rich plasma (PRP) and suspensions of gel-filtered platelets (GFP). Platelets were deposited on C III mainly as surface-bound aggregates. In contrast they were deposited on C IV mainly as spread forms of individual cells. Formation of aggregates on C III was more extensive for PRP than for GFP; in contrast platelet spreading on C IV was more extensive for GFP than for PRP. The effects of an extract of the plant feverfew on platelet-collagen interactions were determined. Feverfew extract inhibited the deposition of /sup 51/Cr-labeled platelets on both C III and C IV in a dose-dependent way. Similar concentrations of extract were needed to inhibit the formation of surface-bound aggregates and to inhibit platelet spreading in both PRP and GFP.

• Research Organization: Institute of Pathological Biochemistry, Medical Academy of Erfurt (Germany, F.R.)
• OSTI ID: 5243275
• Journal Information: Thromb. Res.; (United States), Vol. 48:5
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BLOOD PLATELETS
ADHESION
BLOOD COAGULATION
CHROMIUM 51
COLLAGEN
DOSE-RESPONSE RELATIONSHIPS
ELECTRON MICROSCOPY
SUBSTRATES
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMIUM ISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
MICROSCOPY
NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
SCLEROPROTEINS
550201* - Biochemistry- Tracer Techniques