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Title: Japanese experience with clinical trails of fast neutrons

Abstract

Between November, 1975 and November, 1981, 825 patients were treated with 30 MeV (d-Be) neutrons at the National Institute of Radiological Sciences, Chiba. At the Institute of Medical Science, Tokyo, 302 patients were referred to the Radiation Therapy department and were treated with 16 MeV (d-Be) neutrons. The emphasis of these clinical trials with fast neutrons was placed on the estimation of the effect of fast neutrons for locally advanced cancers or radioresistant cancers, and on evaluation of the rate of complication of normal tissues following irradiaton with fast neutrons. Results were evaluated for patients with previously untreated cancer; local control of the tumor was observed in 59.1%. Complications requiring medical care developed in only 32 patients. Patients who had received pre- or postoperative irradiation were excluded from this evaluation. Late reaction of soft tissue seemed to be more severe than that observed with photon beams. The results also suggest that for carcinoma of the larynx, esophagus, uterine cervix, Pancoasts's tumor of the lung and osteosarcoma, fast neutrons were considered to be effectively applied in this randomized clinical trial. For carcinoma of the larynx, a fast nuetron boost was effectively delivered, although an interstitial implant was necessarily combined with fastmore » neutrons for carcinoma of the tongue. The cumulative survival rate of the patients with carcinoma of the esophagus treated with fast neutrons was 26% compared to the survival rate of 10.5% obtained using photons. This was supported by evidence from the pathological studies that showed that the tumor cells which had deeply invaded into the esophagus were effectively destroyed when fast neutrons were applied.« less

Authors:
 [1]; ; ; ; ; ;
  1. National Inst. of Radiological Sciences, Chiba-shi, Japan
Publication Date:
OSTI Identifier:
5241707
Resource Type:
Journal Article
Journal Name:
Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Additional Journal Information:
Journal Volume: 8:12
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; NEUTRON THERAPY; SIDE EFFECTS; CARCINOMAS; ESOPHAGUS; FAST NEUTRONS; JAPAN; LARYNX; LUNGS; ORAL CAVITY; OSTEOSARCOMAS; PATIENTS; PHOTONS; UTERUS; ASIA; BARYONS; BODY; DIGESTIVE SYSTEM; DISEASES; ELEMENTARY PARTICLES; FEMALE GENITALS; FERMIONS; HADRONS; MASSLESS PARTICLES; MEDICINE; NEOPLASMS; NEUTRONS; NUCLEAR MEDICINE; NUCLEONS; ORGANS; RADIOLOGY; RADIOTHERAPY; RESPIRATORY SYSTEM; SARCOMAS; SKELETAL DISEASES; THERAPY; 550603* - Medicine- External Radiation in Therapy- (1980-); 560151 - Radiation Effects on Animals- Man

Citation Formats

Tsunemoto, H, Arai, T, Morita, S, Ishikawa, T, Aoki, Y, Takada, N, and Kamata, S. Japanese experience with clinical trails of fast neutrons. United States: N. p., 1982. Web. doi:10.1016/0360-3016(82)90564-8.
Tsunemoto, H, Arai, T, Morita, S, Ishikawa, T, Aoki, Y, Takada, N, & Kamata, S. Japanese experience with clinical trails of fast neutrons. United States. https://doi.org/10.1016/0360-3016(82)90564-8
Tsunemoto, H, Arai, T, Morita, S, Ishikawa, T, Aoki, Y, Takada, N, and Kamata, S. 1982. "Japanese experience with clinical trails of fast neutrons". United States. https://doi.org/10.1016/0360-3016(82)90564-8.
@article{osti_5241707,
title = {Japanese experience with clinical trails of fast neutrons},
author = {Tsunemoto, H and Arai, T and Morita, S and Ishikawa, T and Aoki, Y and Takada, N and Kamata, S},
abstractNote = {Between November, 1975 and November, 1981, 825 patients were treated with 30 MeV (d-Be) neutrons at the National Institute of Radiological Sciences, Chiba. At the Institute of Medical Science, Tokyo, 302 patients were referred to the Radiation Therapy department and were treated with 16 MeV (d-Be) neutrons. The emphasis of these clinical trials with fast neutrons was placed on the estimation of the effect of fast neutrons for locally advanced cancers or radioresistant cancers, and on evaluation of the rate of complication of normal tissues following irradiaton with fast neutrons. Results were evaluated for patients with previously untreated cancer; local control of the tumor was observed in 59.1%. Complications requiring medical care developed in only 32 patients. Patients who had received pre- or postoperative irradiation were excluded from this evaluation. Late reaction of soft tissue seemed to be more severe than that observed with photon beams. The results also suggest that for carcinoma of the larynx, esophagus, uterine cervix, Pancoasts's tumor of the lung and osteosarcoma, fast neutrons were considered to be effectively applied in this randomized clinical trial. For carcinoma of the larynx, a fast nuetron boost was effectively delivered, although an interstitial implant was necessarily combined with fast neutrons for carcinoma of the tongue. The cumulative survival rate of the patients with carcinoma of the esophagus treated with fast neutrons was 26% compared to the survival rate of 10.5% obtained using photons. This was supported by evidence from the pathological studies that showed that the tumor cells which had deeply invaded into the esophagus were effectively destroyed when fast neutrons were applied.},
doi = {10.1016/0360-3016(82)90564-8},
url = {https://www.osti.gov/biblio/5241707}, journal = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number = ,
volume = 8:12,
place = {United States},
year = {Wed Dec 01 00:00:00 EST 1982},
month = {Wed Dec 01 00:00:00 EST 1982}
}