Decreased albumin mRNA in immunodeficient wasted' mice
- Loyola Univ. of Chicago, Maywood, IL (United States) Argonne National Lab., IL (United States)
Mice bearing the autosomal recessive gene wst (wst/wst) develop a wasting syndrome' that leads to death by 28-32 days of age. These mice have faulty repair of damage induced by ionizing radiation, immunodeficiency at secretory sites, and neurologic abnormalities. In addition to a progressively more apparent wasted phenotype, wst/wst mice show other features of failure to thrive and malnutrition. Daily body weights of the animals revealed a loss in weight between 25 and 30 days of age, a time during which normal littermates were progressively and rapidly gaining weight. Albumin mRNA levels were measured by dilution dot blot hybridizations of liver-derived RNA preparations from wasted mice, littermates, and parental controls. In all wasted mice, albumin mRNA levels were reduced 5 to 10 fold compared to controls. Northern blots revealed that the albumin mRNA present in wasted mice was normal in length though reduced in amount. These results suggest there may be a relationship between low albumin synthesis and the wasting syndrome of the wst/wst mouse.
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 5240978
- Report Number(s):
- CONF-9104107-; CODEN: FAJOE
- Journal Information:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ALBUMINS
BIOSYNTHESIS
DNA REPAIR
GENES
IMMUNE SYSTEM DISEASES
RADIOINDUCTION
IONIZING RADIATIONS
MESSENGER-RNA
MICE
PHENOTYPE
ANIMALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DISEASES
MAMMALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PROTEINS
RADIATIONS
REPAIR
RNA
RODENTS
SYNTHESIS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals