A comparison of zinc sulfate and oxide absorption in humans using an oral zinc tolerance test

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5240112

English-Westcott, J L; Hambidge, K M; Ellenbogen, L ^[1]

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1. Univ. of Colorado, Denver (United States) Lederle Labs., Pearl River, NY (United States)

The objective of this study was to compare the absorption of zinc from zinc sulfate and zinc oxide, two compounds that are used frequently for zinc supplementation. Absorption of zinc was estimated by an oral zinc tolerance test. At three to five day intervals, each of 16 subjects received either 40 mg of zinc as sulfate, 40 mg of zinc as oxide or 80 ml of water alone. These were administered in a random order, at 0700 hours after a ten hour fast. Plasma zinc was measured at 0, 1, 2, 3, 4, 5, and 6 hours. The areas under the curve were compared in three ways: actual mean plasma zinc values, mean change from the baseline in plasma zinc values, and plasma zinc values after subtracting the control values. The peak plasma zinc, mean {plus minus} SD, occurred two hours after ingestion of the capsules. No increase in plasma zinc values occurred during the control treatment. No significant difference was observed between the response to zinc oxide and zinc sulfate, although both were significantly different from the control treatment. It is concluded that equivalent doses of zinc sulfate and zinc oxide can be used to administer zinc supplementation.

• OSTI ID: 5240112
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

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ZINC
INTESTINAL ABSORPTION
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MAN
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ZINC OXIDES
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