Lung ventilation studies with technetium-99m Pseudogas
Technetium-99m Pseudogas is an ultrafine near monodisperse aerosol of 0.12-microgram diam particle size. This report describes initial clinical experiences with 27 patients referred for investigation of suspected pulmonary embolism, and in whom Pseudogas ventilation images were compared with a high quality commercial aerosol. An additional group of ten patients with severe COPD was examined in a comparative trial of Pseudogas with 81mKr. Pseudogas was better than a conventional aerosol in reaching a diagnosis of pulmonary embolism using a simple blinded comparison with coded images. In addition, bronchial deposition was minimal unless COPD was severe. Moderately well patients had no difficulty inhaling the necessary activity in one or two breaths, and even severely ill and frail aged persons could accomplish the passive breathing maneuver in less than a minute. Clearance of Pseudogas was directly to the systemic circulation with a half-time of 10 min in normal subjects extending up to 100 min in patients with airways disease.
- Research Organization:
- Australian National Univ., Acton
- OSTI ID:
- 5232631
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 6
- Country of Publication:
- United States
- Language:
- English
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EMBOLI
DIAGNOSIS
LUNGS
RADIOISOTOPE SCANNING
RADIOACTIVE AEROSOLS
DIAGNOSTIC USES
AEROSOLS
DTPA
EVALUATION
INHALATION
KRYPTON 81
LUNG CLEARANCE
PATIENTS
TECHNETIUM 99
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
COUNTING TECHNIQUES
DISPERSIONS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
HOURS LIVING RADIOISOTOPES
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KRYPTON ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
SECONDS LIVING RADIOISOTOPES
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TECHNETIUM ISOTOPES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics