Gallium-67 uptake in the lung of asbestos exposed sheep: early association with enhanced macrophage-derived fibronectin accumulation

Journal Article · Tue Apr 01 00:00:00 EST 1986 · J. Nucl. Med.; (United States)

OSTI ID:5229804

Begin, R; Bisson, G; Lambert, R; Cote, Y; Fabi, D; Martel, M; Lamoureux, G; Rola-Pleszczynski, M; Boctor, M; Dalle, D

To evaluate the time course and mechanisms of enhanced /sup 67/Ga lung uptake in asbestosis, we exposed two groups of sheep every 2 wk to either 100 ml saline (controls) or 100 mg UICC chrysotile fibers in 100 ml saline. The sheep were evaluated periodically by pulmonary function tests (PFT), thoracic radiograph (TR), /sup 67/Ga lung scan, bronchoalveolar lavage (BAL), and transbronchial lung biopsy (TLB). By month 24 of the study, 9/15 exposed sheep had developed the initial alveolitis and had significant changes in PFT, TR, and TLB. The other six exposed sheep differed from controls only by a 75% increase in BAL fibronectin until month 30, where significant changes in albumin occurred and /sup 67/Ga scan score increased. The nine sheep with alveolitis had significant sustained increases in /sup 67/Ga scan and BAL levels from month 6, associated with a 150% increase in BAL fibronectin and other parameters of disease activity changed from month 18 to 30. We concluded that in the sheep model of asbestosis, significant changes in /sup 67/Ga scan, /sup 67/Ga BAL counts, and excessive elevation of BAL fibronectin preceded other parameters of disease activity. The data suggest that excessively activated macrophages are primarily responsible for the early /sup 67/Ga lung uptake.

• Research Organization: Universite de Sherbrooke, Quebec
• OSTI ID: 5229804
• Journal Information: J. Nucl. Med.; (United States), Vol. 4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
ASBESTOS
BIOLOGICAL EFFECTS
GALLIUM 67
UPTAKE
LUNGS
RADIOISOTOPE SCANNING
BIOLOGICAL MODELS
BIOPSY
MACROPHAGES
PATHOGENESIS
RESPIRATORY SYSTEM DISEASES
SHEEP
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PHAGOCYTES
RADIOISOTOPES
RESPIRATORY SYSTEM
RUMINANTS
SOMATIC CELLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550601 - Medicine- Unsealed Radionuclides in Diagnostics