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Title: Imaging of cocaine-induced global and regional myocardial ischemia

Abstract

Severe and often fatal cardiac complications have been reported in cocaine users with narrowed coronary arteries caused by atherosclerosis as well as in young adults with normal coronaries. The authors have found that in normal dogs cocaine induces severe temporary hypoperfusion of the left ventricle as indicated by a significantly lower 201Tl concentration compared to the baseline state. The most significant decrease in uptake occurred 5 min after injection and was more pronounced in the septal and apical segments. Following intravenous administration of cocaine, instead of gradual disappearance of 201Tl from the left ventricle, there was continuous increase in 201Tl concentration in the left ventricle. These imaging experiments indicate that the deleterious effects of cocaine on the heart are probably due to spasm of the coronaries and decreased myocardial perfusion. Since spasm of the large subpericardial vessels does not seem to explain the magnitude of the increased coronary resistance and decreased coronary flow after cocaine as described in the literature, it is suggested that microvascular spasm of smaller vessels plays a major role in the temporary decrease in perfusion. The data may also suggest that severe temporary myocardial ischemia is probably the initiating factor for the cardiac complications induced bymore » cocaine.« less

Authors:
; ; ;  [1]
  1. Brookhaven National Laboratory, Medical Department, Upton, New York (USA)
Publication Date:
OSTI Identifier:
5228883
Resource Type:
Journal Article
Journal Name:
Journal of Nuclear Medicine; (United States)
Additional Journal Information:
Journal Volume: 32:8; Journal ID: ISSN 0161-5505
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; COCAINE; BIOLOGICAL EFFECTS; HEART; IMAGE PROCESSING; ISCHEMIA; DIAGNOSIS; DOGS; THALLIUM 201; ALKALOIDS; ANEMIAS; ANESTHETICS; ANIMALS; ANTIDEPRESSANTS; BETA DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HEAVY NUCLEI; HEMIC DISEASES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROCESSING; PSYCHOTROPIC DRUGS; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; SYMPTOMS; THALLIUM ISOTOPES; VASCULAR DISEASES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Oster, Z H, Som, P, Wang, G J, and Weber, D A. Imaging of cocaine-induced global and regional myocardial ischemia. United States: N. p., 1991. Web.
Oster, Z H, Som, P, Wang, G J, & Weber, D A. Imaging of cocaine-induced global and regional myocardial ischemia. United States.
Oster, Z H, Som, P, Wang, G J, and Weber, D A. 1991. "Imaging of cocaine-induced global and regional myocardial ischemia". United States.
@article{osti_5228883,
title = {Imaging of cocaine-induced global and regional myocardial ischemia},
author = {Oster, Z H and Som, P and Wang, G J and Weber, D A},
abstractNote = {Severe and often fatal cardiac complications have been reported in cocaine users with narrowed coronary arteries caused by atherosclerosis as well as in young adults with normal coronaries. The authors have found that in normal dogs cocaine induces severe temporary hypoperfusion of the left ventricle as indicated by a significantly lower 201Tl concentration compared to the baseline state. The most significant decrease in uptake occurred 5 min after injection and was more pronounced in the septal and apical segments. Following intravenous administration of cocaine, instead of gradual disappearance of 201Tl from the left ventricle, there was continuous increase in 201Tl concentration in the left ventricle. These imaging experiments indicate that the deleterious effects of cocaine on the heart are probably due to spasm of the coronaries and decreased myocardial perfusion. Since spasm of the large subpericardial vessels does not seem to explain the magnitude of the increased coronary resistance and decreased coronary flow after cocaine as described in the literature, it is suggested that microvascular spasm of smaller vessels plays a major role in the temporary decrease in perfusion. The data may also suggest that severe temporary myocardial ischemia is probably the initiating factor for the cardiac complications induced by cocaine.},
doi = {},
url = {https://www.osti.gov/biblio/5228883}, journal = {Journal of Nuclear Medicine; (United States)},
issn = {0161-5505},
number = ,
volume = 32:8,
place = {United States},
year = {Thu Aug 01 00:00:00 EDT 1991},
month = {Thu Aug 01 00:00:00 EDT 1991}
}