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Title: (New imaging systems in nuclear medicine)

We continue to use and maintain PCR-I, the single-slice high- resolution high-sensitivity positron emission tomograph, while development proceeds on PCR-II, a three-dimensional PET system. A two-dimensional BGO scintillation detector has been designed and we are nearing completion of the detector, including the light guide, crystals and phototube assembly, and the gantry electronics. We are currently exploring techniques for a very high resolution (sub-mm) PET imaging system. We are using the current PCR-I system to assess changes in presynaptic dopamine receptors and glucose utilization in current biological models of Huntington's disease. Our preliminary studies support the use of the primate (Cynomolgus monkey) model of Huntington's disease to monitor in vivo functional changes. We are planning to extend this study to examine the MPTP model of Parkinson disease, and to assess the therapeutic value of D{sub 1} dopamine receptor agonists for treatment of MPTP-induced neurological defects. 13 refs., 5 figs. (MHB)
Publication Date:
OSTI Identifier:
5228478
Report Number(s):
DOE/ER/60519-T3
ON: DE92000786
DOE Contract Number:
FG02-87ER60519
Resource Type:
Technical Report
Research Org:
Massachusetts General Hospital, Boston, MA (United States). Physics Research Lab.
Sponsoring Org:
DOE; USDOE, Washington, DC (United States)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; BGO DETECTORS; DESIGN; BRAIN; POSITRON COMPUTED TOMOGRAPHY; NERVOUS SYSTEM DISEASES; BIOLOGICAL MODELS; NUCLEAR MEDICINE; RADIATION SOURCES; ANALOG SYSTEMS; BLOOD FLOW; CARBON 11; COMPUTER CODES; COMPUTER NETWORKS; DATA TRANSMISSION; DOPAMINE; FLUORINE 18; FLUORODEOXYGLUCOSE; LIGANDS; MONTE CARLO METHOD; POSITRON CAMERAS; PROGRESS REPORT; RECEPTORS; SCATTERING; SHIELDING; THREE-DIMENSIONAL CALCULATIONS; TISSUE DISTRIBUTION; TWO-DIMENSIONAL CALCULATIONS; AMINES; ANTIMETABOLITES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CAMERAS; CARBON ISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; COMMUNICATIONS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DISTRIBUTION; DOCUMENT TYPES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; FLUORINE ISOTOPES; GAMMA CAMERAS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MEASURING INSTRUMENTS; MEDICINE; MEMBRANE PROTEINS; MINUTES LIVING RADIOISOTOPES; NANOSEC LIVING RADIOISOTOPES; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; PROTEINS; RADIATION DETECTORS; RADIOISOTOPES; SCINTILLATION COUNTERS; SOLID SCINTILLATION DETECTORS; SYMPATHOMIMETICS; TOMOGRAPHY 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics; 440101 -- Radiation Instrumentation-- General Detectors or Monitors & Radiometric Instruments