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Title: Selection for increased desiccation resistance in Drosophila melanogaster: Additive genetic control and correlated responses for other stresses

Previously we found that Drosophila melanogaster lines selected for increased desiccation resistance have lowered metabolic rate and behavioral activity levels, and show correlated responses for resistance to starvation and a toxic ethanol level. These results were consistent with a prediction that increased resistance to many environmental stresses may be genetically correlated because of a reduction in metabolic energy expenditure. Here we present experiments on the genetic basis of the selection response and extend the study of correlated responses to other stresses. The response to selection was not sex-specific and involved X-linked and autosomal genes acting additively. Activity differences contributed little to differences in desiccation resistance between selected and control lines. Selected lines had lower metabolic rates than controls in darkness when activity was inhibited. Adults from selected lines showed increased resistance to a heat shock, {sup 60}Co-gamma-radiation, and acute ethanol and acetic acid stress. The desiccation, ethanol and starvation resistance of isofemale lines set up from the F2s of a cross between one of the selected and one of the control lines were correlated. Selected and control lines did not differ in ether-extractable lipid content or in resistance to acetone, ether or a cold shock.
Authors:
;  [1]
  1. (La Trobe Univ., Bundoora, Victoria (Australia))
Publication Date:
OSTI Identifier:
5222629
Resource Type:
Journal Article
Resource Relation:
Journal Name: Genetics; (USA); Journal Volume: 122:4
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DROSOPHILA; BIOLOGICAL STRESS; ETHANOL; TOXICITY; ACETIC ACID; ACETONE; COBALT 60; ETHERS; FASTING; GAMMA RADIATION; GENES; HEAT; LIPIDS; TOLERANCE; ALCOHOLS; ANIMALS; ARTHROPODS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; COBALT ISOTOPES; DIPTERA; ELECTROMAGNETIC RADIATION; ENERGY; FLIES; FRUIT FLIES; HYDROXY COMPOUNDS; INSECTS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; INVERTEBRATES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KETONES; MINUTES LIVING RADIOISOTOPES; MONOCARBOXYLIC ACIDS; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; RADIATIONS; RADIOISOTOPES; YEARS LIVING RADIOISOT 560300* -- Chemicals Metabolism & Toxicology; 560152 -- Radiation Effects on Animals-- Animals